Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-10

Study Completion Date

2024-11-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction

NCT06368544

Anterior Cruciate Ligament Injuries Cartilage Degeneration

RECRUITING NA

The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

NCT04968665

Anterior Cruciate Ligament Injuries Cartilage Degeneration

UNKNOWN

Ultrasound Evaluation of Hamstring Tendon Regeneration After ACL Reconstruction and Its Influence

NCT04961736

Anterior Cruciate Ligament Injuries

UNKNOWN

Effects of Preoperative Rehabilitation on Tendon Healing, Bone Mineral Density, and Cartilage After ACLR and Patellar Dislocation

NCT05924178

Anterior Cruciate Ligament Rupture

RECRUITING NA

Spatiotemporal Characteristics and Multi-body Dynamics Modeling Information After ACL Rupture and Reconstruction

NCT04462432

Anterior Cruciate Ligament Injuries

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

A total of 26 subjects were recruited for a 60-day period of head-down bed rest (HDBR). The bed rest position is a 6° downward tilt of the head, and all daily activities are performed in this position. We will perform functional MRI scans of the right knee joint using T2 mapping sequences to assess tissue composition and water content before and after HDBR. Functional assessments, including the Y-Balance Test and International Knee Documentation Committee (IKDC) scores, were performed pre-HDBR and post-HDBR.We will divide each participant's knee cartilage into 18 regions and measured T2 values according to the whole organ magnetic resonance imaging score (WORMS) partitioning method.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cartilage Degeneration Weightlessness

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Long term bed rest intervention group

60-day-6° head-down bed rest

Group Type EXPERIMENTAL

60-day-6° head-down bed rest

Intervention Type BEHAVIORAL

Throughout the bed rest period, subjects carried out all activities of daily living-eating, voiding, recreation, and testing

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

60-day-6° head-down bed rest

Throughout the bed rest period, subjects carried out all activities of daily living-eating, voiding, recreation, and testing

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* (1) male; (2) age 25-50 years old; (3) height between 160-175 cm, weight ≥50kg, and BMI between 18.5-26 kg/m²; (4) good general health status.

Exclusion Criteria

* (1) history of alcoholism; (2) smoking ≥5 cigarettes/day in the 3 months before the test; (3) drug dependence or use of medications affecting bone metabolism within 2 weeks before screening; (4) presence of metal implants, severe vertigo, or severe snoring.

Minimum Eligible Age

25 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes