The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration
NCT ID: NCT04968665
Last Updated: 2021-07-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
60 participants
OBSERVATIONAL
2021-08-01
2024-01-01
Brief Summary
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Detailed Description
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Our research studied the joint kinematics and kinetics properties after ACLR and found significant changes in biomechanics in the ACLR knees. Therefore, this study will combine longitude biochemical changes in the cartilage to explore how the alterations in biomechanics would influence biochemical changes in the joint cartilage.
This study will explore the joint biomechanical properties during functional activities by motion analysis, the effects of biomechanical properties on cartilage stress distribution by finite element analysis, the long-term biochemical changes in the joint cartilage by functional MRI. This study will establish prediction models for cartilage biomechanical changes in the mid-term based on joint biomechanical properties in the early stage after ACLR, and cartilage biomechanical changes in the long-term based on joint biomechanical properties in the mid-term after ACLR. The study aims to clarify the mechanism of cartilage degeneration after ACLR and search biomechanical risk factors, in order to provide methods for clinical prevention of cartilage degeneration after ACLR.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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healthy volunteers
gait testing and MRI at baseline for healthy volunteers
gait testing, functional MRI
diagnostic tests including the gait testing and functional MRI
ACL-deficient patients
gait testing and MRI at pre-operation, 6 months post-operation, 1 year post-operation, 2 years post-operation
gait testing, functional MRI
diagnostic tests including the gait testing and functional MRI
Interventions
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gait testing, functional MRI
diagnostic tests including the gait testing and functional MRI
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
Yes
Sponsors
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Peking University Third Hospital
OTHER
Responsible Party
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Ren Shuang
associate researcher
Principal Investigators
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Shuang Ren
Role: PRINCIPAL_INVESTIGATOR
Peking University Third Hospital
Central Contacts
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Other Identifiers
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M2019434
Identifier Type: -
Identifier Source: org_study_id
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