Transversus Thoracic Plane Block for Perioperative Analgesia in Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-01

Study Completion Date

2025-12-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this clinical trial is to learn if perioperative Transversus Thoracic Plane Block (TTPB) decrease perioperative pain after cardiac surgery. The main questions it aims to answer are:

1. does Transversus Thoracic Plane Block decrease perioperative pain after cardiac surgery more than the standard analgesic treatment?
2. Are the results different if the investigators perform Transversus Thoracic Plane Block before surgery or at the end of surgery?

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Transversus Thoracis Muscle Plane Block for Sternotomy Pain in Cardiac Surgery

NCT04596163

Pain, Postoperative Surgical Wound Cardiac Event

COMPLETED NA

Transversus Thoracis Muscle Plane Block for Postoperative Pain in Adult Cardiac Surgery

NCT04591119

Postoperative Pain Chest Pain Coronary Artery Bypass +1 more

COMPLETED NA

Transversus Thoracis Plane Block Versus Parasternal Intercostal Nerve Plane Block for Cardiac Surgery

NCT06155097

Cardiac Surgery

RECRUITING NA

Continuous Paravertebral Block by Intraoperative Direct Access Versus Systemic Analgesia for Postthoracotomy Pain Relief

NCT04482192

Post Thoracotomy Pain

COMPLETED PHASE3

Transversus Thoracic Muscle Plane Block for Open Heart Surgery

NCT04094532

Pain, Acute Pain, Chest

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Transversus Thoracic Plane Block Cardiac Surgery Post Operative Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Placebo

This group receives standard analgesic treatment and no Transversus Thoracic Plane Block is performed

Group Type NO_INTERVENTION

No interventions assigned to this group

Transversus Thoracic Plane Block pre

This group receives standard analgesic treatment and Transversus Thoracic Plane Block is performed before surgery

Group Type ACTIVE_COMPARATOR

Transversus Thoracic Plane Block

Intervention Type PROCEDURE

The Transversus Thoracic Plane Block is a recent regional anesthesia technique. It provides analgesia for the anterior cutaneous branches of the intercostal nerves T2-6 to the medial anterior chest wall via a single injection of local anesthesia between the internal intercostal muscle and the transversus thoracic muscle located between the third and fourth (or fourth and fifth) intercostal space. It is noteworthy that the TTPB can consequently reduce pulmonary morbidity and the need for high-dose opioids.

Transversus Thoracic Plane Block post

This group receives standard analgesic treatment and Transversus Thoracic Plane Block is performed at the end of surgery

Group Type ACTIVE_COMPARATOR

Transversus Thoracic Plane Block

Intervention Type PROCEDURE

The Transversus Thoracic Plane Block is a recent regional anesthesia technique. It provides analgesia for the anterior cutaneous branches of the intercostal nerves T2-6 to the medial anterior chest wall via a single injection of local anesthesia between the internal intercostal muscle and the transversus thoracic muscle located between the third and fourth (or fourth and fifth) intercostal space. It is noteworthy that the TTPB can consequently reduce pulmonary morbidity and the need for high-dose opioids.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Transversus Thoracic Plane Block

The Transversus Thoracic Plane Block is a recent regional anesthesia technique. It provides analgesia for the anterior cutaneous branches of the intercostal nerves T2-6 to the medial anterior chest wall via a single injection of local anesthesia between the internal intercostal muscle and the transversus thoracic muscle located between the third and fourth (or fourth and fifth) intercostal space. It is noteworthy that the TTPB can consequently reduce pulmonary morbidity and the need for high-dose opioids.

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

\- All patients scheduled for cardiac surgery via sternotomy under cardiopulmonary bypass

Exclusion Criteria

* Previous cardiac surgery
* Urgent surgery
* Pregnant women
* Allergy to local anesthetics
* Opioid dependence
* Low ejection fraction \< 30%
* Presence or onset of cognitive or neurological disorders preventing pain assessment
* Infection at injection sites
* Coagulopathy
* Patients on dual antiplatelet therapy
* Renal insufficiency with Glomerular filtration rate (GFR) \< 30 mL/min
* History of thoracic radiotherapy
* History of mastectomy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No