Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-10

Study Completion Date

2026-04-01

Brief Summary

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This study aims to evaluate the safety and efficacy of combined subcostal and lateral transversus abdominis plane (TAP) for postoperative analgesia versus thoracic epidural anesthesia (TEA) in patients undergoing major abdominal cancer surgery.

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Detailed Description

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Postoperative pain is treated using a variety of techniques. It is possible to deliver opioids intravenously, neuraxially, or both.

Thoracic epidural anesthesia (TEA) has long been considered the benchmark for analgesia in major abdominal operations due to its consistent efficacy in pain control and additional benefits such as reduced ileus and improved pulmonary function.

Transversus abdominis plane (TAP) blocks can be a critical component of postoperative pain management, and they play a crucial role in Enhanced Recovery After Surgery (ERAS) protocols, as they significantly affect recovery and patient well-being.

Conditions

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Subcostal Lateral Transversus Abdominis Plane Block Postoperative Analgesia Thoracic Epidural Analgesia Major Abdominal Cancer Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Subcostal and lateral transversus abdominis plane block group

Patients will receive an ultrasound-guided combined subcostal and lateral transversus abdominis plane block.

Group Type EXPERIMENTAL

Subcostal and lateral transversus abdominis plane block

Intervention Type OTHER

Patients will receive an ultrasound-guided combined subcostal and lateral transversus abdominis plane block.

Thoracic epidural anesthesia group

Patients will receive an ultrasound-guided thoracic epidural anesthesia.

Group Type ACTIVE_COMPARATOR

Thoracic epidural anesthesia

Intervention Type OTHER

Patients will receive an ultrasound-guided thoracic epidural anesthesia.

Interventions

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Subcostal and lateral transversus abdominis plane block

Patients will receive an ultrasound-guided combined subcostal and lateral transversus abdominis plane block.

Intervention Type OTHER

Thoracic epidural anesthesia

Patients will receive an ultrasound-guided thoracic epidural anesthesia.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Scheduled for major abdominal surgeries including: (e.g., gastrectomy, colectomy, hepatectomy, cystectomy, total abdominal hysterectomy, Nephrectomy, pancreatectomy).

Exclusion Criteria

* Intraoperative hemodynamic instability.
* History or evidence of coagulopathy.
* Infection or abdominal wall masses at injection site.
* Morbid obesity.
* Other Medical conditions including mental illness or substance abuse.
* Known allergy to local anesthetics.
* Chronic opioid use or chronic pain conditions.
* Pregnancy.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No