Evaluating Adenoma Recurrence After Endoscopic Mucosal Resection With Margin Marking or Post Treatment With Snare Tip Soft Coagulation
NCT ID: NCT06476145
Last Updated: 2026-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
342 participants
OBSERVATIONAL
2023-12-08
2027-01-08
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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EMR-MM
Mucosal markings are placed clearly outside the visible margin of the lesion (polyp) by placing superficial cautery marks with the tip of the endoscopic snare approximately 3 mm away from the polyp margin. Successful marking with diathermy is established by visual identification of white circular "dots" around the entire outer border of the lesion. EMR is then performed as per standard technique as described above.
No interventions assigned to this group
EMR-STSC
Endoscopic mucosal resection with thermal margin ablation (STSC) will be performed of the entire margin of the mucosal defect, by using a light touch with 1 to 2 mm of the exposed snare tip aiming to create a 2 to 3 mm rim of completely ablated tissue around the entire circumference of the resection defect. Successful STSC is confirmed by the presence of a rim of whitening mucosa around the defect
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Ability to provide informed consent
3. Patient scheduled to undergo colonoscopy for the evaluation and removal of colon polyps
4. Non-pedunculated polyps ≥ 20 mm size
Exclusion Criteria
2. Inflammatory bowel disease
3. Inability to provide informed consent
4. Lesions \< 20 mm in size (largest dimension)
5. Lesion involves the lips of the ileocecal valve, is located at the appendiceal orifice and/or is fully circumferential.
6. Any standard contraindication, including pregnancy, to anesthesia and/or colonoscopy
18 Years
ALL
No
Sponsors
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AdventHealth
OTHER
Northwestern University
OTHER
White River Junction Veterans Affairs Medical Center
FED
Rush University
OTHER
University Medical Centre Ljubljana
OTHER
University of Kansas
OTHER
Henry Ford Health System
OTHER
Carilion Clinic
OTHER
St. Paul's Hospital, Canada
OTHER
Minneapolis Veterans Affairs Medical Center
FED
Responsible Party
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Principal Investigators
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Dennis Yang, MD
Role: PRINCIPAL_INVESTIGATOR
AdventHealth
Locations
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AdventHealth
Orlando, Florida, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Other Identifiers
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1880214
Identifier Type: -
Identifier Source: org_study_id
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