Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-07-03

Study Completion Date

2027-07-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery.

The main questions are:

1. Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia?
2. Do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery?
3. Do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Personalizing Preprocedural Sedation for Regional Anesthesia

NCT05579509

Catastrophizing Pain

COMPLETED EARLY_PHASE1

Influence of Preoperative Fear on Pain and Postoperative Outcomes

NCT06785389

Fear Pain Management Anxiety +1 more

RECRUITING

Evaluating the Benefit of Hypnoanalgesia Versus Neuroleptanalgesia During Hand Surgery

NCT06185829

Hand Surgery

RECRUITING NA

Memory & Conditioning Under Anesthesia

NCT04062123

Anesthesia Pain

COMPLETED PHASE1

The Effect of Anxiety on Perioperative Pain: Patient and Provider Perception

NCT04363281

Pain

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

A patient's psychological profile importantly modulates pain severity, and the overall experience and impact of pain. For instance, catastrophic thinking about pain, including magnification, rumination, and helplessness, is associated with both greater pain severity and impact.

Over the years, regional anesthesia has become an integral part of multimodal pain management for many surgeries. Regional anesthesia (epidural and peripheral nerve blocks) to be associated with superior pain control, reduced time to return of bowel function, shorter intraoperative times, fewer side effects and complications, earlier ambulation and functional exercise capacity post-discharge, lower in-hospital mortality, reduced length-of-stay, improved patient satisfaction, and fewer readmissions.

The investigators aim to use of validated psychosocial surveys and semi-structured interviews to understand the phenotype of patients who will benefit the most from regional anesthesia. The investigators also aim to understand how different patient phenotypes and regional anesthesia affect perioperative opioid consumption, and development of chronic postsurgical pain.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Pain Chronic Post Operative Pain Opioid Use

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Thoracic surgery and open abdominal surgery

Patients who underwent surgery thoracic surgery or open abdominal surgery

regional anesthesia

Intervention Type PROCEDURE

Patients who underwent surgery and received an epidural or peripheral nerve block

no regional anesthesia

Intervention Type PROCEDURE

Patients who underwent surgery and did not received an epidural or peripheral nerve block

Orthopedic surgery

Patients who underwent orthopedic surgery

regional anesthesia

Intervention Type PROCEDURE

Patients who underwent surgery and received an epidural or peripheral nerve block

no regional anesthesia

Intervention Type PROCEDURE

Patients who underwent surgery and did not received an epidural or peripheral nerve block

Spine surgery

Patients who underwent spine surgery

acute pain consultation

Intervention Type OTHER

Patients who underwent surgery and had a perioperative (preop, intraop, or postop) acute pain consultation

no acute pain consultation

Intervention Type OTHER

Patients who underwent surgery and did not have a perioperative (preop, intraop, or postop) acute pain consultation

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

regional anesthesia

Patients who underwent surgery and received an epidural or peripheral nerve block

Intervention Type PROCEDURE

no regional anesthesia

Patients who underwent surgery and did not received an epidural or peripheral nerve block

Intervention Type PROCEDURE

acute pain consultation

Patients who underwent surgery and had a perioperative (preop, intraop, or postop) acute pain consultation

Intervention Type OTHER

no acute pain consultation

Patients who underwent surgery and did not have a perioperative (preop, intraop, or postop) acute pain consultation

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age ≥ 18
* English speaking
* Surgical or procedural patient who will be admitted postoperatively
* Willingness to answer psychosocial survey and/or audio recorded semi-structured interview