Effects of Agility and Perturbation Based Training in Addition to Routine Physical Therapy

NCT ID: NCT06460662

Last Updated: 2024-10-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 26 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-06-30
• Study Completion Date: 2024-10-10

Brief Summary

Osteoarthritis is a degenerative joint disease. Knee OA patients sometimes report episodes of knee instability that limit their ADLs. The episodes of instability are similar to those reported in knee ligament injuries. It is believed that modifications of interventions that are used to promote knee stability in knee ligament injuries can be used in knee OA to enhance knee stability and function. The purpose of this study will be to determine the effects of agility and perturbation-based training in addition to routine physical therapy on pain, function, quality of life and disability in knee osteoarthritis.

Detailed Description

A Randomized Clinical Trial will be conducted at Al Syed Touqeer Altaf Surgical Hospital through a convenience sampling technique on 26 patients, which will be allocated using computer-generated randomization into two groups. Group A will be treated with agility and perturbation training techniques in addition to the same routine physical therapy as Group B, and Group B will receive only routine physical therapy. Outcome measures will be conducted through NPRS, WOMAC, SF-36, and KOS-ADLs questionnaires. All the outcome measures will be assessed pre and post-treatment, and the assessor will be blind. Frequency of the treatment will be 3 sessions per week for 4 weeks. Data will be analyzed using SPSS software version 25.

Conditions

Knee Osteoarthritis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Agility and perturbation training group

Group A will receive agility and perturbation training techniques in addition to the same routine physical therapy as Group B.

The Agility training exercises include:

• Side Stepping
• Braiding Activities
• Front and Back Crossover Steps During Forward Ambulation
• Multiple Changes in Direction During Walking on Therapist Command

The perturbation training exercises include:

• Double-Leg Foam Balance Activity
• Tilt board Balance Training
• Rollerboard and Platform Perturbations

Group Type: EXPERIMENTAL

Routine Physical Therapy

Intervention Type: OTHER

Group B: Routine physical therapy Group that includes:

• Calf Stretching
• Hamstring Stretching
• Prone Quadriceps Stretching
• Long-Sitting Knee Flexion and Extension
• Quadriceps setting
• Supine Straight Leg Raises
• Prone Hip Extensions
• Standing Hamstring Curls With Cuff Weights
• Standing Calf Raises
• Treadmill Walking
• Mobilization techniques

Routine physical therapy

Group B: Routine physical therapy Group that includes:

• Calf Stretching
• Hamstring Stretching
• Prone Quadriceps Stretching
• Long-Sitting Knee Flexion and Extension
• Quadriceps setting
• Supine Straight Leg Raises
• Prone Hip Extensions
• Standing Hamstring Curls With Cuff Weights
• Standing Calf Raises
• Treadmill Walking
• Mobilization techniques

Group Type: ACTIVE_COMPARATOR

Routine Physical Therapy

Intervention Type: OTHER

Group B: Routine physical therapy Group that includes:

• Calf Stretching
• Hamstring Stretching
• Prone Quadriceps Stretching
• Long-Sitting Knee Flexion and Extension
• Quadriceps setting
• Supine Straight Leg Raises
• Prone Hip Extensions
• Standing Hamstring Curls With Cuff Weights
• Standing Calf Raises
• Treadmill Walking
• Mobilization techniques

Interventions

Routine Physical Therapy

Group B: Routine physical therapy Group that includes:

• Calf Stretching
• Hamstring Stretching
• Prone Quadriceps Stretching
• Long-Sitting Knee Flexion and Extension
• Quadriceps setting
• Supine Straight Leg Raises
• Prone Hip Extensions
• Standing Hamstring Curls With Cuff Weights
• Standing Calf Raises
• Treadmill Walking
• Mobilization techniques

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Both male and female.
• Subjects with Kellgren and Lawrence grade II and III osteoarthritis.
• OA diagnosed subjects according to American College of Rheumatology ACR criteria;

• Morning stiffness ≤ 30 minutes.
• Crepitus with active motion of the knee (while weight bearing).
• Tenderness to palpation of the bony margins of the joint, bony enlargement, and no palpable warmth.

Exclusion Criteria

• Ligament or meniscal injury around the knee.
• Suffering from acute synovitis
• Neuromuscular disorders.
• Cognitive impairments.
• Required use of an assistive device for ambulation.
• Reported a history of 2 or more falls within the previous year.
• Undergone total knee arthroplasty.
• Uncontrolled hypertension, history of cardiovascular disease, neurological disorders that affected lower extremity function.
• Severe visual problems.

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Riphah International University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Maryam Ijaz, MSPT*

Role: PRINCIPAL_INVESTIGATOR

Riphah International University,Lahore

Locations

Sher Shah Road, Shadbagh

Lahore, Punjab Province, Pakistan

Countries

Pakistan

References

Lange AK, Vanwanseele B, Fiatarone Singh MA. Strength training for treatment of osteoarthritis of the knee: a systematic review. Arthritis Rheum. 2008 Oct 15;59(10):1488-94. doi: 10.1002/art.24118.

Reference Type: BACKGROUND

PMID: 18821647 (View on PubMed)

Hicks-Little CA, Peindl RD, Hubbard-Turner TJ, Cordova ML. The Relationship Between Early-Stage Knee Osteoarthritis and Lower-Extremity Alignment, Joint Laxity, and Subjective Scores of Pain, Stiffness, and Function. J Sport Rehabil. 2016 Aug;25(3):213-8. doi: 10.1123/jsr.2014-0170. Epub 2016 Jul 21.

Reference Type: BACKGROUND

PMID: 27445119 (View on PubMed)

Michael JW, Schluter-Brust KU, Eysel P. The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Dtsch Arztebl Int. 2010 Mar;107(9):152-62. doi: 10.3238/arztebl.2010.0152. Epub 2010 Mar 5.

Reference Type: BACKGROUND

PMID: 20305774 (View on PubMed)

Samson DJ, Grant MD, Ratko TA, Bonnell CJ, Ziegler KM, Aronson N. Treatment of primary and secondary osteoarthritis of the knee. Evid Rep Technol Assess (Full Rep). 2007 Sep;(157):1-157.

Reference Type: BACKGROUND

PMID: 18088162 (View on PubMed)

Collins NJ, Hart HF, Mills KAG. Osteoarthritis year in review 2018: rehabilitation and outcomes. Osteoarthritis Cartilage. 2019 Mar;27(3):378-391. doi: 10.1016/j.joca.2018.11.010. Epub 2018 Dec 7.

Reference Type: BACKGROUND

PMID: 30529739 (View on PubMed)

Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P. OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage. 2007 Sep;15(9):981-1000. doi: 10.1016/j.joca.2007.06.014. Epub 2007 Aug 27.

Reference Type: BACKGROUND

PMID: 17719803 (View on PubMed)

Jamtvedt G, Dahm KT, Christie A, Moe RH, Haavardsholm E, Holm I, Hagen KB. Physical therapy interventions for patients with osteoarthritis of the knee: an overview of systematic reviews. Phys Ther. 2008 Jan;88(1):123-36. doi: 10.2522/ptj.20070043. Epub 2007 Nov 6.

Reference Type: BACKGROUND

PMID: 17986496 (View on PubMed)

Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008 Feb;16(2):137-62. doi: 10.1016/j.joca.2007.12.013.

Reference Type: BACKGROUND

PMID: 18279766 (View on PubMed)

Other Identifiers

REC/RCR & AHS/23/0193 Maryam

Identifier Type: -

Identifier Source: org_study_id