Effects of Muscle Energy Technique in Knee Osteoarthritis Patients

NCT ID: NCT05349565

Last Updated: 2023-07-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 26 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-09-13
• Study Completion Date: 2023-07-10

Brief Summary

To determine the effectiveness of muscle energy technique along conventional physical therapy after mesenchymal stem cell transplantation in knee Osteoarthritis patients regarding Pain, range of motion, functional disability and quality of life.

Detailed Description

Mesenchymal stem cells (MSCs) replacement is a regenerative therapeutic procedures for the early treatment of cartilaginous defects in knee osteoarthritis. MSCs may improve symptoms and function in osteoarthritic joints but also decrease inflammation and induce cartilage healing by differentiating into chondrocytes, osteoblasts and indicating appropriate extracellular matrix proteins (i.e. collagen I and II) through the secretion of cytokines, chemokines, and growth factors from MSCs.

Conditions

Knee Osteoarthritis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

CONVENTIONAL PHYSICAL THERAPY

TENS , Open chain knee flexion and extension, Calf stretch , Quad set

Group Type: ACTIVE_COMPARATOR

CONVENTIONAL PHYSICAL THERAPY

Intervention Type: OTHER

High frequency TENS for 10 mins, 3 days/week Ankle pumps for blood circulation 10 repetitions x1 set, 3 days/week. Heel slides10 repetitions x1 set, 3 days/week. Open chain knee flexion and extension 10 repetitions x1 set, 3 days/week. SLR (straight leg raise) 10 repetitions x1 set, 3 days/week. Calf stretch 10 repetitions x1 set, 3 days/week. Quad set 10 repetitions x1 set, 3 days/week.

Total 6 sessions each consisting of 30-45 minutes

MUSCLE ENERGY TECHNIQUE

MET ( isometric contraction with 6-10 sec )

Group Type: EXPERIMENTAL

MUSCLE ENERGY TECHNIQUE

Intervention Type: OTHER

Experimental group treated by applying Muscle energy technique along conventional physical therapy.

For MET patient is positioned at maximal comfort and lengthening while engaging the barrier and then patient is asked to perform isometric contraction with 6-10 sec hold and then release and lengthen the muscle 4-5 repetition x 1 set, 3days/week Total 6 sessions each consisting of 30-45 minutes

Interventions

CONVENTIONAL PHYSICAL THERAPY

High frequency TENS for 10 mins, 3 days/week Ankle pumps for blood circulation 10 repetitions x1 set, 3 days/week. Heel slides10 repetitions x1 set, 3 days/week. Open chain knee flexion and extension 10 repetitions x1 set, 3 days/week. SLR (straight leg raise) 10 repetitions x1 set, 3 days/week. Calf stretch 10 repetitions x1 set, 3 days/week. Quad set 10 repetitions x1 set, 3 days/week.

Total 6 sessions each consisting of 30-45 minutes

Intervention Type: OTHER

MUSCLE ENERGY TECHNIQUE

Experimental group treated by applying Muscle energy technique along conventional physical therapy.

For MET patient is positioned at maximal comfort and lengthening while engaging the barrier and then patient is asked to perform isometric contraction with 6-10 sec hold and then release and lengthen the muscle 4-5 repetition x 1 set, 3days/week Total 6 sessions each consisting of 30-45 minutes

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Both male and female
• Age > 40 years
• Knee osteoarthritis patients undergone mesenchymal stem cell transplantation.

Exclusion Criteria

• History of recent or past septic arthritis
• Patients with neurological deficit
• Uncontrolled diabetes
• Malignancy
• Vascular insufficiency

• Minimum Eligible Age: 41 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Riphah International University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

KINZA ANWAR, MS-OMPT

Role: PRINCIPAL_INVESTIGATOR

RIPHAH INTERNATIONAL UNIVERSITY,ISLAMABAD,PAKISTAN

Locations

Institute of Regenerative medicine

Islamabad, , Pakistan

Countries

Pakistan

Other Identifiers

REC/01255 Fanila Ashraf

Identifier Type: -

Identifier Source: org_study_id