Changing Trunk Muscle Activation in Patients With Recurrent Low Back Pain in Remission

NCT ID: NCT06452030

Last Updated: 2024-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

55 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-29

Study Completion Date

2025-10-01

Brief Summary

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The first aim of the study is to investigate the effects of a single therapy session on trunk muscle activation and lumbopelvic sensorimotor control in persons with recurrent low back pain in remission.

The second aim of the study is to examine the convergent validity of (in)voluntary multifidus activation by means of inspection and palpation during two clinically assessed lumbopelvic sensorimotor control tests in persons with recurrent low back pain in remission. The convergent validity will be examined by calculating the relationship between (1) the clinical score of (in)voluntary multifidus activation, (2) back muscle activation during the same tests measured simultaneously with electromyography and (3) trunk muscle activation during other functional movements measured with electromyography.

The third aim of the study is to investigate the convergent validity of a left-right discrimination test by calculating the relationship between (1) the left-right discrimination test, (2) position-reposition test, (3) the Fremantle Back Awareness Questionnaire and (4) the Photograph Series of Daily Activities Scale.

Detailed Description

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Low back pain (LBP) is a very common musculoskeletal disorder. Previous research has already demonstrated that trunk muscle function and sensorimotor control (SMC) are altered in people with LBP, which may be an important underlying mechanism contributing to their pain. While there is some evidence regarding the immediate effects of exercise therapy on back muscle function (i.e., earlier onset of activity after one therapy session), the effects of a single therapy session on functional movements and clinically assessed SMC tests in patients with recurrent LBP in remission have never been investigated.

Inspection and palpation are often used in clinical settings to detect lumbopelvic SMC changes in people with LBP. If lumbopelvic SMC changes are noted during the clinical examination, specific SMC therapy can be implemented into the treatment plan. Thus, it is critical that the clinically assessed lumbopelvic SMC tests are sufficiently valid. An important prerequisite is that the clinically assessed SMC parameter is related to objectively measured SMC parameters during the same test. However, clinically assessed lumbopelvic SMC tests are often performed in standardized and less functional positions (e.g., prone lying). As such, the question arises whether results from clinically assessed SMC tests are associated with objective SMC parameters evaluated during functional activities relevant for the individual patient (e.g., lifting). Our systematic review showed that only one clinically assessed lumbopelvic SMC test had sufficient convergent validity with low quality of evidence (Brandt et al., 2024). Moreover, no studies investigated the relationships between clinically assessed lumbopelvic SMC tests and objectively measured SMC parameters during a functional task. Further high-quality studies are therefore needed.

In addition, the left-right discrimination test is also accessible in clinical settings. The left-right discrimination test assesses a person's body perception. During this test, the participant must view images on a computer of a person with the trunk flexed or rotated to the left or right. The participant must indicate as quickly and accurately as possible which side of the trunk of the person in the image is bent or turned. Another way to assess body perception is by using the Fremantle Back Awareness Questionnaire, of which the Dutch version was recently validated. It has been suggested that body perception is the result of the interaction of internal "body maps," sensory information, motor output, and beliefs and perceptions about the body. However, the relationship between the left-right discrimination test, the position-reposition test, and the Fremantle Back Awareness Questionnaire has not yet been explored.

Conditions

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Recurrent Low Back Pain Remission

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The study model is parallel. Participants with recurrent low back pain in remission will be randomly allocated to receive either (1) specific sensorimotor control training, (2) general extension training or (3) fascia therapy (i.e. parallel study model).
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Specific sensorimotor control training

One low-load treatment session of selective multifidus activation.

Group Type EXPERIMENTAL

Specific sensorimotor control training

Intervention Type BEHAVIORAL

Participants allocated to the specific motor control group will receive sensorimotor training of the multifidus muscle.

Aspecific extension training

One low-load treatment session of back muscle activation.

Group Type ACTIVE_COMPARATOR

Aspecific extension training

Intervention Type BEHAVIORAL

Participants allocated to the aspecific group will receive spinal extension exercises.

Fascia training

One low-load treatment session of general movement exercises.

Group Type EXPERIMENTAL

Fascia training

Intervention Type BEHAVIORAL

Participants allocated to the fascia group will receive general movement exercises.

Interventions

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Specific sensorimotor control training

Participants allocated to the specific motor control group will receive sensorimotor training of the multifidus muscle.

Intervention Type BEHAVIORAL

Aspecific extension training

Participants allocated to the aspecific group will receive spinal extension exercises.

Intervention Type BEHAVIORAL

Fascia training

Participants allocated to the fascia group will receive general movement exercises.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. People between 18-65 years old
2. Having recurrent non-specific low back pain (LBP) in remission at enrolment:

* At least 2 episodes of LBP/year, with an 'episode' implying pain lasting a minimum of 24 hours which is preceded and followed by at least 1 month without LBP
* Minimum LBP intensity during episodes should be ≥2/10 on a numeric rating scale (NRS) from 0 to 10
* During remission the NRS intensity for LBP should be 0-1/10.
3. Having a dominant flexion movement pattern/ neutral movement pattern

Exclusion Criteria

1. People \<18 years old or \>65 years old
2. Having any other type of non-specific LBP (acute, subacute, chronic).
3. Having an active extension movement pattern
4. Having any type of blood clotting disorder
5. People with upper-limb complaints that prevent them from exerting (maximum) force with their arms or hands.
6. People that received specific sensorimotor control training or fascia-training in the previous year
7. People with serious underlying conditions (e.g., multiple sclerosis) or severe scoliosis
8. People with a history of spine surgery
9. Pregnant women and women who have given birth in the year before enrolment
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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VZW Educatieve Lichaamsbeweging

UNKNOWN

Sponsor Role collaborator

University Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lieven Danneels, Prof

Role: PRINCIPAL_INVESTIGATOR

University Ghent

Locations

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Ghent University

Ghent, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Lieven Danneels, Prof

Role: CONTACT

+32 9 332 26 35

Thomas Matheve, Prof

Role: CONTACT

Facility Contacts

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Lieven Danneels, Prof

Role: primary

+32 9 332 26 35

Thomas Matheve, Prof

Role: backup

References

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de Vet HC, Heymans MW, Dunn KM, Pope DP, van der Beek AJ, Macfarlane GJ, Bouter LM, Croft PR. Episodes of low back pain: a proposal for uniform definitions to be used in research. Spine (Phila Pa 1976). 2002 Nov 1;27(21):2409-16. doi: 10.1097/01.BRS.0000030307.34002.BE.

Reference Type BACKGROUND
PMID: 12438991 (View on PubMed)

Stanton TR, Latimer J, Maher CG, Hancock MJ. A modified Delphi approach to standardize low back pain recurrence terminology. Eur Spine J. 2011 May;20(5):744-52. doi: 10.1007/s00586-010-1671-8. Epub 2010 Dec 31.

Reference Type BACKGROUND
PMID: 21193932 (View on PubMed)

Tsao H, Hodges PW. Immediate changes in feedforward postural adjustments following voluntary motor training. Exp Brain Res. 2007 Aug;181(4):537-46. doi: 10.1007/s00221-007-0950-z. Epub 2007 May 3.

Reference Type BACKGROUND
PMID: 17476489 (View on PubMed)

Tsao H, Druitt TR, Schollum TM, Hodges PW. Motor training of the lumbar paraspinal muscles induces immediate changes in motor coordination in patients with recurrent low back pain. J Pain. 2010 Nov;11(11):1120-8. doi: 10.1016/j.jpain.2010.02.004.

Reference Type BACKGROUND
PMID: 20434958 (View on PubMed)

Matheve T, Hodges P, Danneels L. The Role of Back Muscle Dysfunctions in Chronic Low Back Pain: State-of-the-Art and Clinical Implications. J Clin Med. 2023 Aug 24;12(17):5510. doi: 10.3390/jcm12175510.

Reference Type BACKGROUND
PMID: 37685576 (View on PubMed)

Hodges PW, Danneels L. Changes in Structure and Function of the Back Muscles in Low Back Pain: Different Time Points, Observations, and Mechanisms. J Orthop Sports Phys Ther. 2019 Jun;49(6):464-476. doi: 10.2519/jospt.2019.8827.

Reference Type BACKGROUND
PMID: 31151377 (View on PubMed)

Hebert JJ, Koppenhaver SL, Teyhen DS, Walker BF, Fritz JM. The evaluation of lumbar multifidus muscle function via palpation: reliability and validity of a new clinical test. Spine J. 2015 Jun 1;15(6):1196-202. doi: 10.1016/j.spinee.2013.08.056. Epub 2013 Oct 4.

Reference Type BACKGROUND
PMID: 24314767 (View on PubMed)

Meier R, Iten P, Luomajoki H. Clinical assessments can discriminate altered body perception in patients with unilateral chronic low back pain, but not differences between affected and unaffected side. Musculoskelet Sci Pract. 2019 Feb;39:136-143. doi: 10.1016/j.msksp.2018.12.006. Epub 2018 Dec 21.

Reference Type BACKGROUND
PMID: 30593940 (View on PubMed)

Brandt M, Danneels L, Meirezonne H, Van Oosterwijck J, Willems T, Matheve T. Clinically assessed lumbopelvic sensorimotor control tests in low back pain: are they actually valid? A systematic review according to COSMIN guidelines. Musculoskelet Sci Pract. 2024 Jun;71:102953. doi: 10.1016/j.msksp.2024.102953. Epub 2024 Apr 7.

Reference Type BACKGROUND
PMID: 38604022 (View on PubMed)

Other Identifiers

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ONZ-2022-0310

Identifier Type: -

Identifier Source: org_study_id

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