How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?
NCT ID: NCT06384495
Last Updated: 2025-08-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
TERMINATED
NA
3 participants
INTERVENTIONAL
2024-07-15
2025-08-10
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Information gained from this study will serve to fill knowledge gaps on the duration of effect of cerebellar tDCS and the effects of polarity.
The purpose of this study is to determine the duration of effect of ventro-lateral cerebellar transcranial direct current stimulation (tDCS) in healthy adults through cortical excitability (CE), cognitive, language and motor assessment measures. Primary aim: Compare baseline CE from left motor cortex of first dorsal interosseous (FDI) and orbicularis oris (OO) areas to CE post cerebellar tDCS at 15 minutes, 45 minutes and 75 minutes. Single-pulse and paired-pulse transcranial magnetic stimulation (TMS) will be used to measure and compare stimulus response curve (S/R curve), cortical silent period (CSP) and short-interval intracortical inhibition (SICI) in the hand area and facial area of the left primary motor cortex at each time point.
Secondary aim: Compare baseline performance on cognition, motor learning and language tasks to performance at 15, 45 and 75 minutes after receiving tDCS. Digit Symbol Substitution Test (DSST), Serial Reaction Time Test (SRTT) and Lexical Decision tasks will be presented via a computer interface.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effect of ctDCS During Balance Training on Cerebellar Ataxia
NCT04039048
Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments
NCT05479006
Exploring Cerebellar Inhibition of the Motor Cortex in Stroke Patients
NCT02401698
Priming With tDCS: Expanding the Window of Recovery in Chronic Stroke
NCT03964467
Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke
NCT06381388
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Real anodal tDCS group (REAL-A)
Participants randomized to REAL-A
REAL-A
one session of 2mA for 20 minutes to the right ventro-lateral cerebellum
Real cathodal tDCS group (REAL-C)
Participants randomized to REAL-C
REAL-C
one session of 2mA for 20 minutes to the right ventro-lateral cerebellum
Sham group (SHAM)
Participants randomized to SHAM group
SHAM
one session of sham tDCS for 20 minutes to the right ventro-lateral cerebellum.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
REAL-A
one session of 2mA for 20 minutes to the right ventro-lateral cerebellum
REAL-C
one session of 2mA for 20 minutes to the right ventro-lateral cerebellum
SHAM
one session of sham tDCS for 20 minutes to the right ventro-lateral cerebellum.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* must be fluent in English
* have adequate vision to see a computer screen from 12-18 inches, fine motor skills to press a key on a computer keyboard and hearing to hear directions and questions provided by the researcher
* Individuals must also be able to read words and phrases
Exclusion Criteria
* history of seizures
* neurologic injury including concussion/head injury or stroke or other neurologic conditions
* History of documented learning disabilities and/or ADHD
* Metal implants in the body (excluding dental fillings), psoriasis or eczema affecting the scalp.
18 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of Minnesota
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Sharyl Samargia-Grivette
Role: PRINCIPAL_INVESTIGATOR
University of Minnesota
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University of Minnesota
Minneapolis, Minnesota, United States
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
STUDY00021475
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.