Effect of Transcranial Magnetic Stimulation on Recovery of Upper Limb Among Stroke Survivors

NCT ID: NCT01938690

Last Updated: 2021-02-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-02-28
• Study Completion Date: 2013-12-31

Brief Summary

Approximately two thirds of stroke survivors have profoundly impaired function of the upper limb. Currently the main stay of the treatment for upper limb motor function is rehabilitation therapy focusing on repetitive and skillful task practice (task-oriented therapy) which has been shown to induce substantial functional reorganization in the undamaged motor cortex and functional recovery. In spite of rehabilitation therapy, functional recovery of arm and hand function is limited to one third of stroke survivors and there is a great need for adjunct treatment to current practice. Repetitive Transcranial Magnetic Stimulation (rTMS) is a noninvasive means of stimulating nerve cells in superficial areas of the brain and emerging as a novel method of modulating cortical excitability and promoting functional recovery after stroke. There have been studies using rTMS to improve motor function after stroke. However, whether 1Hz rTMS can enhance the effect of the task-oriented therapy on upper limb function after stroke has not been investigated. In this pilot proposal, we intend to investigate the feasibility of 1Hz rTMS on unaffected hemisphere as an adjunct to task-oriented therapy to improve upper limb motor function among stroke patients. The information obtained from this pilot study will provide a platform for the future randomized control trials combining the rTMS and task-oriented therapy to enhance motor recovery among stroke survivors.

Detailed Description

See above.

Conditions

Stroke

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Sham stimulation

Sham stimulation on the scalp of unaffected brain

Group Type: SHAM_COMPARATOR

Transcranial magnetic stimulation (TMS)

Intervention Type: DEVICE

8 sessions of TMS followed by task specific training

transcranial magnetic stimulation

transcranial magnetic stimulation on unaffected brain

Group Type: EXPERIMENTAL

Transcranial magnetic stimulation (TMS)

Intervention Type: DEVICE

8 sessions of TMS followed by task specific training

Interventions

Transcranial magnetic stimulation (TMS)

8 sessions of TMS followed by task specific training

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

--≥18 years of age

• Ability to give informed consent
• An unilateral ischemic stroke of onset 6-36 months prior to the study
• No other known brain abnormalities by medical history or by MRI
• Affected upper limb function of score 2-6 in Chedoke Arm and Hand Inventory
• Enrolled or planned to be enrolled in occupational therapy at Kessler Institute for Rehabilitation as an outpatient

Exclusion Criteria

• More than one stroke (Transient Ischemic Attack not a reason for exclusion) Neurological conditions other than stroke (brain tumor, Parkinson's disease, etc)
• History of epilepsy or unprovoked seizures
• Family history of epilepsy (father, mother, children, siblings with diagnosis of epilepsy)
• Implanted medical devices (pacemakers, defibrillators, medical pump, implanted brain stimulator, aneurysm clip, carotid or cerebral stents, central venous catheter, cochlear implant, internal hearing aids)
• Damaged skin or skull of head
• Excessive spasticity of upper limb as indicated by Modified Ashworth Spasticity Scale >2/4
• Recent injection of antispastic medications (Botulinum toxin, phenol) of the last 3 months or scheduled such injection during the study period
• Severe sensory deficits as measured by a score of 2 on item 8 of the National Institute of Health (NIH) stroke scale
• Severe aphasia as measured by a score of ≥2 on item 9 of NIH stroke scale
• Being determined to be medically unstable by a physician
• Being pregnant or trying to become pregnant
• Past or current alcohol abuse, illicit drug use, or significant mental illness (schizophrenia, major depression, manic disorders)
• Working with metal currently or in the past
• Tattoo with metal based ink on the head or neck
• Unable to answer the questionnaires in the consent form correctly

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Kessler Foundation

OTHER

Sponsor Role: lead

Responsible Party

A. M. Barrett, MD

Director Stroke Lab

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

A.M. Barrett, MD

Role: STUDY_DIRECTOR

Kessler Foundation

Locations

Kessler Foundation

West Orange, New Jersey, United States

Countries

United States

Other Identifiers

R-758-12

Identifier Type: -

Identifier Source: org_study_id