Successful Aging and Age-related Decline

NCT ID: NCT06376656

Last Updated: 2024-04-19

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 400 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-05-20
• Study Completion Date: 2030-05-31

Brief Summary

Recent studies have shown promising cognitive and physical interventions aimed at slowing down ageing-related declines in quality of life, but they lack strong ecological validity (brief durations, unrealistic goals, no real-world application) and has yet to show robust evidence that such interventions are stable and suitable in the long-term. The investigators aim to examine whether these interventions can, over four years, significantly slow down the normal rate of ageing-related decline.

Detailed Description

This is a longitudinal, controlled, cohort study. The overarching aim in this intervention study is three-fold: (1) to test hypotheses derived from ageing-related theories, (2) to provide robust measurable evidence both in the long-term and validate meaningful interventions, and (3) provide quantifiable cost-benefit ratio to suggested solutions. A cohort of Malaysian older adults will be recruited and assigned to one of the groups, either cognitive stimulation, physical activity, combined cognitive stimulation and physical activity, or non-intervention control.

Conditions

Aging; Elderly; Cognitive Decline; Physical Decline; Intervention Study

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Cognitive stimulation

Participants will take part in psychoeducation, videogaming, book club and technology training workshops.

Group Type: EXPERIMENTAL

Cognitive stimulation

Intervention Type: BEHAVIORAL

The cognitive stimulation will comprise of psychoeducation, videogaming, book club and technology training workshop sessions. Participants will take part in weekly sessions that are an hour long each.

For every six months, the participants will alternate between psychoeducation, videogaming, book club and technology training workshop sessions.

Physical activity

Participants will take part in walking, Zumba, resistance exercise and aerobics sessions.

Group Type: EXPERIMENTAL

Physical activity

Intervention Type: BEHAVIORAL

The physical activity intervention will comprise of walking, Zumba, resistance exercise and aerobics sessions. Participants will take part in weekly sessions that are an hour long each.

For every six months, the participants will alternate between walking, Zumba, resistance exercise and aerobics sessions until the end of intervention period.

Combined intervention

Participants will take part in both cognitive stimulation and physical activity intervention sessions.

Group Type: EXPERIMENTAL

Cognitive stimulation

Intervention Type: BEHAVIORAL

The cognitive stimulation will comprise of psychoeducation, videogaming, book club and technology training workshop sessions. Participants will take part in weekly sessions that are an hour long each.

For every six months, the participants will alternate between psychoeducation, videogaming, book club and technology training workshop sessions.

Physical activity

Intervention Type: BEHAVIORAL

The physical activity intervention will comprise of walking, Zumba, resistance exercise and aerobics sessions. Participants will take part in weekly sessions that are an hour long each.

For every six months, the participants will alternate between walking, Zumba, resistance exercise and aerobics sessions until the end of intervention period.

Non-intervention control

Participants will not take part in any intervention.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Cognitive stimulation

The cognitive stimulation will comprise of psychoeducation, videogaming, book club and technology training workshop sessions. Participants will take part in weekly sessions that are an hour long each.

For every six months, the participants will alternate between psychoeducation, videogaming, book club and technology training workshop sessions.

Intervention Type: BEHAVIORAL

Physical activity

The physical activity intervention will comprise of walking, Zumba, resistance exercise and aerobics sessions. Participants will take part in weekly sessions that are an hour long each.

For every six months, the participants will alternate between walking, Zumba, resistance exercise and aerobics sessions until the end of intervention period.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Healthy and this includes those seeking regular medical attention,
• Have some form of mobility (ability to walk short distances at least 3m),
• Able to communicate in at least one of the following languages: English, Malay, Mandarin, Tamil.

Exclusion Criteria

• Older adults with a history of stroke,
• Diagnosis of neurodegenerative diseases (such as Alzheimer's disease or Parkinson's) or psychiatric disorders,
• Uncorrected auditory and/or visual impairments,
• Currently on psychiatric medications,
• Immobile,
• Require full-time caregiver assistance,
• With comprehension impediments from the assessment portion of this project,
• A Montreal Cognitive Assessment (MoCA) score of <13.

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sunway University

OTHER

Sponsor Role: lead

Responsible Party

YookChin Chia

Professor, Head of Department of Medical Sciences, School of Medical and Life Sciences and Programme Leader of Postgraduate Diploma In Primary Care For Elderly

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yook Chin Chia Professor, Datin, Dr, MBBS, FRCP

Role: PRINCIPAL_INVESTIGATOR

Sunway University

Tin Tin Su

Role: STUDY_CHAIR

Monash University

Rozainee Khairudin

Role: STUDY_CHAIR

The National University of Malaysia

Nur Ain Shahrier

Role: STUDY_CHAIR

Sunway University

Audrey Wei Ling Lim

Role: STUDY_CHAIR

Sunway University

Locations

Sunway University

Petaling Jaya, Selangor, Malaysia

Site Status: RECRUITING

Countries

Malaysia

Central Contacts

Yook Chin Chia Professor, Head of Department of Medical Sciences, MBBS; FRCP

Role: CONTACT

ycchia@sunway.edu.my

+60374918622 ext. 7410

Facility Contacts

Michael J Jenkins, PhD

Role: primary

michaeljj@sunway.edu.my

+60374918622 ext. 7183

References

Bogataj S, Mesaric KK, Pajek M, Petrusic T, Pajek J. Physical exercise and cognitive training interventions to improve cognition in hemodialysis patients: A systematic review. Front Public Health. 2022 Oct 14;10:1032076. doi: 10.3389/fpubh.2022.1032076. eCollection 2022.

Reference Type: BACKGROUND

PMID: 36311587 (View on PubMed)

Erickson KI, Leckie RL, Weinstein AM. Physical activity, fitness, and gray matter volume. Neurobiol Aging. 2014 Sep;35 Suppl 2:S20-8. doi: 10.1016/j.neurobiolaging.2014.03.034. Epub 2014 May 14.

Reference Type: BACKGROUND

PMID: 24952993 (View on PubMed)

Murman DL. The Impact of Age on Cognition. Semin Hear. 2015 Aug;36(3):111-21. doi: 10.1055/s-0035-1555115.

Reference Type: BACKGROUND

PMID: 27516712 (View on PubMed)

Ogawa T, Hirose Y, Honda-Ogawa M, Sugimoto M, Sasaki S, Kibi M, Kawabata S, Ikebe K, Maeda Y. Composition of salivary microbiota in elderly subjects. Sci Rep. 2018 Jan 11;8(1):414. doi: 10.1038/s41598-017-18677-0.

Reference Type: BACKGROUND

PMID: 29323208 (View on PubMed)

Wells PM, Sprockett DD, Bowyer RCE, Kurushima Y, Relman DA, Williams FMK, Steves CJ. Influential factors of saliva microbiota composition. Sci Rep. 2022 Nov 7;12(1):18894. doi: 10.1038/s41598-022-23266-x.

Reference Type: BACKGROUND

PMID: 36344584 (View on PubMed)

Yong MH, Lawrie L, Schaefer A, Phillips LH. The Effects of Adult Aging and Culture on Theory of Mind. J Gerontol B Psychol Sci Soc Sci. 2022 Feb 3;77(2):332-340. doi: 10.1093/geronb/gbab093.

Reference Type: BACKGROUND

PMID: 34036302 (View on PubMed)

Other Identifiers

LRGS/1/2019/SYUC/02/1

Identifier Type: -

Identifier Source: org_study_id