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Neuroplasticity: The Effects of Exercise Training on Cognitive and Affective Functioning of Older People

NCT ID: NCT04641429

Last Updated: 2020-11-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-02

Study Completion Date

2021-10-31

Brief Summary

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This study investigates the effects of exercise on older people's cognitive and affective functions, and the possible underlying neurobiological pathways.

Detailed Description

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Population aging is accelerating. The socioeconomic burden associated with an aging population calls for timely action for promoting brain health. The human brain has the capacity for plastic reorganization through learning and experience. Physical activity could induce plasticity and is important in the prevention of functional decline and increased survival. In this study, the effects of Qigong and stretching exercise on affective and cognitive function among the healthy elderly are investigated. This study is proposed to invite 200 participants (100 in each intervention condition). The investigators acquire data from questionnaires, assessments, neurocognitive tests, magnetic resonance imaging and blood samples at baseline (before the intervention) and post-intervention.

Conditions

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Healthy Ageing

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

In this intervention study, each participant is allocated to either the Qigong or stretching exercise training group in a pseudo-randomized order based on the recruitment orders and their availability.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Blinding the participants to the allocation is impossible due to the nature of intervention. But prior to the first training session, participants have no knowledge on which type of training they are going to receive.

Study Groups

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Qigong

Participants in the experimental group receive Qigong exercise training.

Group Type EXPERIMENTAL

Qigong exercise

Intervention Type BEHAVIORAL

Participants in the experimental group receive 12-week group-based Qigong exercise training.

stretching

Participants in the control group receive stretching exercise training.

Group Type ACTIVE_COMPARATOR

Stretching exercise

Intervention Type BEHAVIORAL

Participants in the control group receive 12-week group-based stretching exercise training.

Interventions

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Qigong exercise

Participants in the experimental group receive 12-week group-based Qigong exercise training.

Intervention Type BEHAVIORAL

Stretching exercise

Participants in the control group receive 12-week group-based stretching exercise training.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. At least finished primary school;
2. Have normal or corrected-to-normal vision and hearing;
3. Ability to do exercise;
4. Right-hand dominance;
5. Normal cognitive ability as assessed by the Montreal Cognitive Assessment Hong Kong version (HK-MoCA).

Exclusion Criteria

1. Abmormal anxiety or depression mood as measured by the Hospital Anxiety and Depression Scale;
2. Current diagnosis or history of neurological or psychological conditions, such as substance abuse, psychotic disorders, or affective disorders;
3. Current diagnosis or history of substance/alcohol abuse;
4. Contraindications for MRI scanning (e.g. implanted metal);
5. People who regularly practice any qigong, Tai Chi or similar exercise or meditation within 6 months before study;
6. People who regularly practice moderate to high intensity physical exercise within 6 months before study. The operational definition of 'regular practice' is three times a week or more, at least 30 mins per time for at least 3 months.
Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Professor Tatia Mei-chun LEE

Chair Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tatia Lee, PhD

Role: PRINCIPAL_INVESTIGATOR

The University of Hong Kong

Locations

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The University of Hong Kong

Hong Kong, , Hong Kong

Site Status RECRUITING

Countries

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Hong Kong

Central Contacts

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Tatia Lee, PhD

Role: CONTACT

Phone: 852-39178394

Email: [email protected]

Facility Contacts

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Tatia Lee, PhD

Role: primary

References

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Qi D, Wong NML, Shao R, Man ISC, Wong CHY, Yuen LP, Chan CCH, Lee TMC. Qigong exercise enhances cognitive functions in the elderly via an interleukin-6-hippocampus pathway: A randomized active-controlled trial. Brain Behav Immun. 2021 Jul;95:381-390. doi: 10.1016/j.bbi.2021.04.011. Epub 2021 Apr 17.

Reference Type DERIVED
PMID: 33872709 (View on PubMed)

Other Identifiers

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UW 19-005

Identifier Type: -

Identifier Source: org_study_id