Acute Effects of Dietary Medium-chain Fatty Acids on Lipid Profile

NCT ID: NCT06368271

Last Updated: 2024-04-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 4 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-10-01
• Study Completion Date: 2024-02-28

Brief Summary

In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.

Detailed Description

Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days.

On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.

Conditions

Healthy Nutrition; Diet, Healthy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Intake of fatty acids

,Participants ingest a test drink containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk) within five min. Blood and oxygen uptake are obtained frequently during the following 4 hours.

Group Type: EXPERIMENTAL

Lipidomics

Intervention Type: DIETARY_SUPPLEMENT

Health beneficial effects of medium-chain fatty acids

Interventions

Lipidomics

Health beneficial effects of medium-chain fatty acids

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

healthy males BMI:20-27 recreationally physical active non-smoker no medicine

-

Exclusion Criteria

• high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Copenhagen

OTHER

Sponsor Role: lead

Responsible Party

Bente Kiens

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Bente Kiens, D.sci, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Locations

University of Copenhagen

Copenhagen, , Denmark

Department of Nutrition, Exercise and Sports

Copenhagen, , Denmark

Countries

Denmark

Other Identifiers

Lipidomix

Identifier Type: -

Identifier Source: org_study_id