The Effects of Pain and Pain Relief on Peripheral Nerve Excitability

NCT ID: NCT06356376

Last Updated: 2024-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-20

Study Completion Date

2024-04-30

Brief Summary

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This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief.

The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.

Detailed Description

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Conditions

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Analgesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy Participants

Heat Stimulation

Intervention Type DEVICE

Heat stimulation at a painful, but to the subject tolerable level.

Interventions

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Heat Stimulation

Heat stimulation at a painful, but to the subject tolerable level.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Healthy Participants able to give informed consent.

Exclusion Criteria

* Chronic pain conditions
* Neurological or Psychiatric disease
* Other major diseases
* Pain medication within the last 24 hours
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lundbeck Foundation

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Danish Pain Research Center

Aarhus N, , Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Alexander G Kristensen, MD, PhD

Role: CONTACT

+45 93 52 28 64

Facility Contacts

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Alexander G Kristensen, MD,PhD

Role: primary

+45 93 52 28 64

Other Identifiers

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UAarhus_AGK_MNG_2

Identifier Type: -

Identifier Source: org_study_id

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