A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing
NCT ID: NCT03576053
Last Updated: 2020-07-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
59 participants
INTERVENTIONAL
2018-07-01
2019-08-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Histamine+cowhage+heat
Histamine
Skin Prick Test with Histamine
Cowhage
Manually skin insertion of cowhage spicules
Heat stimulation
Short heat stimulation
Histamine+cowhage+serotonin+pre-heating
Histamine
Skin Prick Test with Histamine
Cowhage
Manually skin insertion of cowhage spicules
Pre-heating
Mild skin pre-heating
Serotonin
Serotonin electrophoresis
lidocaine and saline+heat
Lidocaine
Lidocaine intradermal injection
Heat stimulation
Short heat stimulation
Interventions
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Lidocaine
Lidocaine intradermal injection
Histamine
Skin Prick Test with Histamine
Cowhage
Manually skin insertion of cowhage spicules
Heat stimulation
Short heat stimulation
Pre-heating
Mild skin pre-heating
Serotonin
Serotonin electrophoresis
Eligibility Criteria
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Inclusion Criteria
* Age 18-60 years
* Able to speak and understand English
Exclusion Criteria
* Pregnancy or lactation
* Prior experience of adverse effects from anaesthetic, specifically Lidocaine
* Drug addiction defined as the use of cannabis, opioids or other drugs - 5 -
* Previous neurologic, musculoskeletal or mental illnesses
* Lack of ability to cooperate
* Current use of medications that may affect the trial
* Active skin diseases
* Active participation in other experiments currently ongoing or within the last 14 days
* Tattoos on volar forearms that will interfere with local skin measurements
18 Years
60 Years
ALL
Yes
Sponsors
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Aalborg University
OTHER
Responsible Party
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Daniele Riccio
Principal investigator
Principal Investigators
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Daniele Riccio, MSc
Role: PRINCIPAL_INVESTIGATOR
Aalborg University
Locations
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Aalborg University
Aalborg, North Denmark, Denmark
Countries
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Other Identifiers
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N-20180035
Identifier Type: -
Identifier Source: org_study_id
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