Comparison of High and Low Pulse Energy Dusting Protocols Using Holmium: YAG-laser in Flexible Ureteroscopy for Renal Stones Treatment

NCT ID: NCT06338137

Last Updated: 2024-04-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 160 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-08-25
• Study Completion Date: 2024-01-01

Brief Summary

Rcompare high-energy versus low-energy laser settings in renal stone lithotripsy using low power machines) Holmium YAG 30 watts, examining their respective advantages, limitations, and overall efficacy.

Detailed Description

The prevalence of urinary stone disease treatment has shown a continuous updating Within the armamentarium of urinary stone management, the laser has emerged as a cornerstone for lithotripsy in endourological procedures. The laser technology has witnessed a progressive evolution, transitioning from the established holmium: yttrium-aluminum-garnet (Ho:YAG) laser with pulse modulation to the advent of thulium fiber laser (TFL) and, more recently, the innovative pulsed thulium:YAG (p-Tm:YAG) laser Laser lithotripsy is prefered for its minimally invasive approach and high success rates in fragmenting stones, yet the ongoing debate continues regarding the optimal laser power settings for this procedure. contemporary approaches in laser lithotripsy focus on two primary strategies: fragmenting stones into smaller retrievable parts or breaking them into minute fragments, commonly referred to as 'dust,' facilitating the natural passage of smaller particles The choice between high power and low power settings in laser lithotripsy significantly influences treatment outcomes, including stone fragmentation efficiency, procedural time, and potential tissue damage. High-energy power laser settings offer rapid stone ablation capabilities, enabling quick fragmentation but potentially raising concerns about thermal injury to surrounding tissues. In contrast, low-energy power settings, while reducing the risk of tissue damage, might prolong the procedure and necessitate additional maneuvers for complete stone clearance This study aims to compare high-energy versus low-energy laser settings in renal stone lithotripsy using low power machines) Holmium YAG 30 watts, examining their respective advantages, limitations, and overall efficacy. By scrutinizing existing literature and recent studies, this study intends to provide a 56 comprehensive understanding of the clinical implications of choosing optimal laser settings in urolithiasis comprehensive understanding of the clinical implications of choosing optimal laser settings in urolithiasis.

Conditions

Renal Stone

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

high-energy patients

Use high energy in stone management

Group Type: OTHER

Holmium Yag laser

Intervention Type: DEVICE

Use two laser energy low and high to reach the optimal setting for stone dusting

Low energy patient

Use low energy in stone management

Group Type: OTHER

Holmium Yag laser

Intervention Type: DEVICE

Use two laser energy low and high to reach the optimal setting for stone dusting

Interventions

Holmium Yag laser

Use two laser energy low and high to reach the optimal setting for stone dusting

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• adult patients
• hard renal stones
• less than 2 cm
• Hounsfield unit of ≥ 1000

Exclusion Criteria

• Patients less than 18 years
• ureteral stones
• stones with Hounsfield units less than 1000
• stones in calyceal diverticulum
• patients with coagulopathy were also excluded from the study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Menoufia University

OTHER

Sponsor Role: lead

Responsible Party

Hossam Kandeel

Director

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Hossam Kandeel

Shibīn al Kawm, State Or Province, Egypt

Countries

Egypt

Other Identifiers

4-2024urol

Identifier Type: -

Identifier Source: org_study_id