Signs of Central Sensitization in Tension-type Headache

NCT ID: NCT06323720

Last Updated: 2024-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

66 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-23

Study Completion Date

2025-12-31

Brief Summary

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The goal of this observational study is to assess the pain sensitivity in tension-type headache patients. The main question it aims to answer is:

\- Are signs of central sensitization present in tension-type headache?

Participants will be asked to fill out baseline questionnaires and they will be assessed during 1 test moment (static and dynamic quantitative sensory testing).

Researchers will compare tension-type headache patients with healthy controls to see if signs of central sensitization are only present in the tension-type headache group.

Detailed Description

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Conditions

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Tension-Type Headache

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Episodic tension-type headache

Patients with 1 - 14 days of TTH/month.

Quantitative Sensory Testing

Intervention Type OTHER

Assessment of the heat and cold pain thresholds, temporal summation, conditioned pain modulation, pressure pain thresholds, electrical pain thresholds, and withdrawal reflex.

Chronic tension-type headache

Patients with more than 14 days TTH/month

Quantitative Sensory Testing

Intervention Type OTHER

Assessment of the heat and cold pain thresholds, temporal summation, conditioned pain modulation, pressure pain thresholds, electrical pain thresholds, and withdrawal reflex.

Healthy controls

Participants without tension-type headache

Quantitative Sensory Testing

Intervention Type OTHER

Assessment of the heat and cold pain thresholds, temporal summation, conditioned pain modulation, pressure pain thresholds, electrical pain thresholds, and withdrawal reflex.

Interventions

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Quantitative Sensory Testing

Assessment of the heat and cold pain thresholds, temporal summation, conditioned pain modulation, pressure pain thresholds, electrical pain thresholds, and withdrawal reflex.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Diagnosis of tension headache according to globally recognized criteria (ICHD-3) or verified by a physician
2. Diagnosis of tension headache confirmed by a questionnaire (Headache Screening Questionnaire)
3. Not pregnant or given birth in the past year since a change in hormone levels can affect pain experience
4. Adults between the ages of 18 and 65
5. Proficient in the Dutch language

Exclusion Criteria

1. Other diagnosis of headache or a mixed form
2. Other existing condition involving central nervous system sensitivity
3. Other structural neurological syndromes
4. Any condition involving the brain in the past
5. Procedure on the head, neck, or shoulder in the past 3 years
6. Currently suffering from a psychiatric condition
7. Athletes competing at a competitive level
8. Not proficient in the Dutch language
9. Currently pregnant.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jessica Van Oosterwijck, Prof

Role: PRINCIPAL_INVESTIGATOR

Revalidatiewetenschappen en kinesitherapie

Locations

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Ghent University

Ghent, East-Flanders, Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Jessica Van Oosterwijck, Prof

Role: CONTACT

+32 9 332 69 19

Facility Contacts

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Jessica Van Oosterwijck, Prof.

Role: primary

Other Identifiers

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ONZ-2023-0442

Identifier Type: -

Identifier Source: org_study_id

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