Muscle Soreness and Stiffness in Patients With Chronic or Frequent Episodic Tension Type Headache.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2017-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim is to investigate muscle soreness and stiffness in patients with Chronic or Frequent Episodic Tension Type Headache before and after treatment with amitriptyline - and to compare the results with healthy individuals.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Muscle Tenderness and Hardness in Migraine Patients

NCT03626805

Migraine Disorders Muscle Tenderness Headache Disorders, Primary +2 more

COMPLETED

Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2

NCT00257985

Familial Hemiplegic Migraine Type 1 and 2 Healthy Volunteers

COMPLETED NA

Day to Day Variation of Pressure Pain Threshold and Muscle Hardness

NCT03632928

Migraine Disorders Tenderness, Muscle Headache Disorders

COMPLETED

Examination of Muscle Stiffness, Tenderness and Pressure Pain Thresholds During a Cycle of Botulinum Toxin A Treatment in Chronic Migraine Patients

NCT05328687

Chronic Migraine

COMPLETED

Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine

NCT00541736

Familial Hemiplegic Migraine

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The muscle stiffness is measured with ultrasonic shear wave elastography in m. masseter, m. sternocleidomastoid and m. Trapezius.

The muscle soreness is measured by palpation of the muscles aided by a so called palpometer.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Tension-type Headache

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Tension type headache

The investigator measures the muscle soreness and muscle stiffness before the patients starts their prescribed treatment with amitriptyline - and again after they have reached their optimal dosage of amitriptyline.

Group Type ACTIVE_COMPARATOR

Amitriptyline

Intervention Type DRUG

The investigator recruits patients who have already discussed and agreed to the amitriptyline treatment with their physician. The patients start the treatment after the investigator have measured them once.

Healthy controls

The investigator measures the muscle soreness and muscle stiffness once.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Amitriptyline

The investigator recruits patients who have already discussed and agreed to the amitriptyline treatment with their physician. The patients start the treatment after the investigator have measured them once.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Saroten Tricyclic antidepressants

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Chronic Tension type headache or frequent episodic tension type headache with at least ten episodes or more per month throughout three months or more.
* Pericranial muscle tenderness

Exclusion Criteria

* Other primary headache disorder (with the exception of episodic migraine.)
* Pregnancy or ongoing breastfeeding
* Heart disease that contradicts treatment with amitriptyline
* Drug or substance abuse

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes