Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?
NCT ID: NCT01161017
Last Updated: 2017-10-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
67 participants
INTERVENTIONAL
2008-07-31
2014-05-31
Brief Summary
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Can successful prevention of migraine be coupled to a psychophysical pain modulation profile?
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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1 Amitriptyline.
Amitriptyline
Amitriptyline
Initial dose of 12.5mg will be given for 2 days. Then, daily 25mg will be taken for additional 8 weeks
2 Topiramate
Topiramate
Topiramate
For the first 5 days of treatment 25mg is prescribed and should be ingested in one evening dose. For another 5 days, 25g dose should be taken twice a day (morning and evening). For the next 5 days, morning dose will be 25mg; evening dose will be 50mg. For the remaining 6 weeks of treatment, a dose of 50mg twice a day will be advised
Interventions
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Amitriptyline
Initial dose of 12.5mg will be given for 2 days. Then, daily 25mg will be taken for additional 8 weeks
Topiramate
For the first 5 days of treatment 25mg is prescribed and should be ingested in one evening dose. For another 5 days, 25g dose should be taken twice a day (morning and evening). For the next 5 days, morning dose will be 25mg; evening dose will be 50mg. For the remaining 6 weeks of treatment, a dose of 50mg twice a day will be advised
Eligibility Criteria
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Inclusion Criteria
* age 18-75,
* without any other chronic pain.
Exclusion Criteria
* language or cognitive dysfunction precluding use of psychophysics.
18 Years
75 Years
ALL
No
Sponsors
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Rambam Health Care Campus
OTHER
Responsible Party
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d_yarnitsky
Head of Neurology Department
Locations
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Rambam Medical Center
Haifa, , Israel
Countries
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Other Identifiers
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Migraine06CTIL
Identifier Type: -
Identifier Source: org_study_id