Familial and Environmental Factors Behind Migraine

NCT ID: NCT04356079

Last Updated: 2020-04-22

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-04-30
• Study Completion Date: 2020-08-31

Brief Summary

Migraine is a chronic neurological disease characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms. Migraines are believed to be due to a mixture of environmental and genetic factors. About two-thirds of cases run in families. Changing hormone levels may also play a role, as migraines affect slightly more boys than girls before puberty, but about two to three times more women than men after puberty. The risk of migraines usually decreases during pregnancy. The exact mechanisms of migraine are not known. It is, however, believed to be a neurovascular disorder. The primary theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem.

Detailed Description

Environmental influences play a role, but family studies suggest that defective genes may be primarily involved in disease causation. The mode of transmission of typical migraine in families is still unclear, but it is widely believed to be multifactorial although a role for a major susceptibility gene cannot be excluded. Aim of study: we aim to study the familial risk for developed migraine and its relation to EEG changes.

Conditions

Migraine

Study Design

• Observational Model Type: FAMILY_BASED
• Study Time Perspective: RETROSPECTIVE

Study Groups

Migraine patients

International Headache Society Test

Intervention Type: DIAGNOSTIC_TEST

Thorough History of Patients and families

Control

International Headache Society Test

Intervention Type: DIAGNOSTIC_TEST

Thorough History of Patients and families

Interventions

International Headache Society Test

Thorough History of Patients and families

Intervention Type: DIAGNOSTIC_TEST

Other Intervention Names

Family Pedigree Chart

Eligibility Criteria

Inclusion Criteria

• Fullfilled Migraine chriteria

Exclusion Criteria

• Genereal Neurologic Disease

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Amal Mohamed Aly Tohamy

Ass. Prof.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Amal Tohamy, MD

Role: CONTACT

tohamy.amal@gmail.com

00201221783835

Other Identifiers

FEFM

Identifier Type: -

Identifier Source: org_study_id