Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2010-10-31
2011-12-31
Brief Summary
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Detailed Description
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Migraine is an independent risk factor for stroke, especially in young women with aura symptoms. Endothelial dysfunction is a risk factor for cardiovascular diseases. Recent studies suggest that there is a link between migraine with aura and endothelial activation, dysfunction and impaired vascular reactivity.
In this case-control study the investigators examine several novel biomarkers of endothelial function such as endothelial progenitor cells and endothelial microparticles as well as novel methods such as reactive hyperemic peripheral arterial tonometry in female migraineurs with aura and age-matched controls.
Conditions
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Study Design
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CASE_CONTROL
OTHER
Study Groups
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migraine group
female migraineurs with aura
No interventions assigned to this group
control group
healthy women without headache syndrome
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* age \< 50
* female gender
Exclusion Criteria
* cardiovascular disease (stroke, coronary heart disease, myocardial infarction)
* vasculitis
* peripheral artery disease
* diabetes mellitus
* pregnancy
* drug abuse
* medication: statin, anticoagulation, aspirin, clopidogrel
* intake of triptans \<24h
18 Years
50 Years
FEMALE
Yes
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Thomas Liman
MD MSC
Principal Investigators
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Thomas Liman, MD
Role: PRINCIPAL_INVESTIGATOR
Center for Stroke Research Berlin, Charité Campus Mitte
Locations
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Center for Stroke Research Berlin
Berlin, , Germany
Countries
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References
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Liman TG, Neeb L, Rosinski J, Wellwood I, Reuter U, Doehner W, Heuschmann PU, Endres M. Peripheral endothelial function and arterial stiffness in women with migraine with aura: a case-control study. Cephalalgia. 2012 Apr;32(6):459-66. doi: 10.1177/0333102412444014. Epub 2012 Apr 20.
Liman TG, Bachelier-Walenta K, Neeb L, Rosinski J, Reuter U, Bohm M, Endres M. Circulating endothelial microparticles in female migraineurs with aura. Cephalalgia. 2015 Feb;35(2):88-94. doi: 10.1177/0333102414529671. Epub 2014 Apr 8.
Liman TG, Neeb L, Rosinski J, Reuter U, Endres M. Stromal Cell-Derived Factor-1 Alpha Is Decreased in Women With Migraine With Aura. Headache. 2016 Sep;56(8):1274-9. doi: 10.1111/head.12839. Epub 2016 May 30.
Other Identifiers
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FF_NCRC_Migraine&ED
Identifier Type: -
Identifier Source: org_study_id
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