QST, Blink Reflex and Nociceptive Flexion Reflex in Headache

NCT ID: NCT04585698

Last Updated: 2020-10-14

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 40 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-10-31
• Study Completion Date: 2021-10-31

Brief Summary

The aim of this study is to compare central and peripheric sensitization in headache patients at Baseline (T0) and 1 month after (T1) a treatment with an anti-CGRP (Fremanezumab-Ajovy).

Detailed Description

20 patients and 20 healthy subjects will be enrolled. The headache patients will be recruited just before starting their treatment and 1 month after (corresponding to the efficacy peak). Hot and cold stimulations will be delivered with the ATS probe from the Medoc Pathway on the forehead and on the hand (palmar face) to determine painful threshold to warm/cold stimuli. A blink reflex will be generated with a concentric electrode placed over the eyebrow and with active/earth electrodes linked to the EMG machine for the recording. For the nociceptive flexion reflex, a cutaneous stimulation will be applied on the arm and the response recorded on the corresponding muscles.

Conditions

Head Pain

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

headache patients

No interventions assigned to this group

healthy subjects

No interventions assigned to this group

Eligibility Criteria

Exclusion Criteria

• medication changes 1 month prior to the test
• neuropathy
• acute or chronic pain
• medications having effects on the central nervous system
• other disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Liege

OTHER

Sponsor Role: lead

Responsible Party

Manise Maite

Doctor in Medical Sciences

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

ULiege_CHEPS_AM_MM_JS

Identifier Type: -

Identifier Source: org_study_id