A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess STS101 in the Acute Treatment of Migraine

NCT ID: NCT04940390

Last Updated: 2023-11-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1591 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-30

Study Completion Date

2022-10-26

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Study STS101-007 is a randomized, double-blind, parallel group, placebo-controlled, multicenter study to evaluate the efficacy, safety, and tolerability of single doses of STS101 (dihydroergotamine nasal powder) in the acute treatment of migraine.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Study STS101-007 is a multi-center, single-dose, randomized, double-blind, placebo-controlled, parallel group study in subjects with acute migraine (ages 18 to 65 years).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Migraine Migraine With Aura Migraine Without Aura

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

STS101

STS101 (dihydroergotamine nasal powder)

Group Type EXPERIMENTAL

Dihydroergotamine

Intervention Type DRUG

Dihydroergotamine is a semi-synthetic derivative of ergotamine tartrate.

STS101 Placebo

STS101 Placebo

Group Type EXPERIMENTAL

Placebo

Intervention Type DRUG

Placebo for STS101

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dihydroergotamine

Dihydroergotamine is a semi-synthetic derivative of ergotamine tartrate.

Intervention Type DRUG

Placebo

Placebo for STS101

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Dihydroergotamine Mesylate STS101 Placebo

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Males or females, 18-65 years of age at the time of Screening Visit
* Subject has at least 1-year history of migraines (with or without aura), according to the International Classification of Headache Disorder, 3rd Edition (ICHD3)

Exclusion Criteria

* Pregnant or breast-feeding women
* Women of child-bearing potential not using or not willing to use highly effective contraception.
* Diagnosis of headache conditions other than migraine with or without aura, including diagnosis of basilar or hemiplegic migraines or cluster headache.
* History of coronary artery disease, coronary artery vasospasm (including Printz-metals' angina), clinically significant arrhythmia or, peripheral vascular disease, ischemic disease (e.g. Raynaud's syndrome, ischemic bowel syndrome, angina pectoris, myocardial infarction, or documented silent ischemia); percutaneous coronary intervention, or cardiac surgery.
* History of cerebrovascular disease, including but not limited to stroke, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage.
* Diagnosis of major depression with current symptoms, psychosis, alcohol abuse or dependence, drug abuse or dependence, major psychiatric conditions (e.g. schizophrenia, psychosis or Bipolar disorder), dementia. Other significant neurological or psychiatric disorders (including other pain syndromes or risk of suicide) that in the opinion of the investigator might interfere with study participation and assessments or subject safety.
* Any clinically significant symptoms or conditions, including but not limited to central nervous system (e.g., seizures), cardiac, pulmonary, metabolic, renal, hepatic or gastrointestinal conditions or history of such conditions that, in the opinion of the investigator might interfere with study assessments or safety of participant.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Satsuma Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Detlef Albrecht, MD

Role: STUDY_CHAIR

Satsuma Pharmaceuticals, Inc.

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

MD First Research

Chandler, Arizona, United States

Site Status

Elite Clinical Studies

Phoenix, Arizona, United States

Site Status

Alliance For Multispecialty Research

Tempe, Arizona, United States

Site Status

Cognitive Clinical Trials, LLC

Tempe, Arizona, United States

Site Status

Clinedge, LLC

Tucson, Arizona, United States

Site Status

ERG Clinical

Little Rock, Arkansas, United States

Site Status

Hope Clinical Research

Canoga Park, California, United States

Site Status

Wr-Pri, Llc

Encino, California, United States

Site Status

Neuro-Pain Medical Center Ince

Fresno, California, United States

Site Status

Estudy Site - La Mesa

La Mesa, California, United States

Site Status

Wr-Pri Llc

Los Alamitos, California, United States

Site Status

Downtown LA Research Center

Los Angeles, California, United States

Site Status

Clinical Research Institute

Los Angeles, California, United States

Site Status

Wr-Pri Llc

Newport Beach, California, United States

Site Status

Artemis Institute for Clinical Research - San Diego

San Diego, California, United States

Site Status

WR-MCCR

San Diego, California, United States

Site Status

Acclaim Clinical Research

San Diego, California, United States

Site Status

National Research Institute, A Clinical Research Organization

Santa Ana, California, United States

Site Status

Alpine Clinical Research Center, Inc

Boulder, Colorado, United States

Site Status

Clinedge, LLC

Cromwell, Connecticut, United States

Site Status

Neurology Offices of South Florida

Boca Raton, Florida, United States

Site Status

Velocity Clinical Research, Hallendale Beach

Hallandale, Florida, United States

Site Status

Infinity Clinical Research, LLC

Hollywood, Florida, United States

Site Status

Elite Research Network, LLC a Florida LLC

Jacksonville, Florida, United States

Site Status

Clinical Neuroscience Solutions, Inc

Jacksonville, Florida, United States

Site Status

Elite Research Network LLC a Florida LLC

Jupiter, Florida, United States

Site Status

Multi-Specialty Research Associates

Lake City, Florida, United States

Site Status

Clinicloud

Maitland, Florida, United States

Site Status

Next Phase Research

Miami, Florida, United States

Site Status

Applemed Research Group

Miami, Florida, United States

Site Status

Biotech Pharmaceuticals Group LLC

Miami, Florida, United States

Site Status

Novel Clinical Research Center LLC

Miami, Florida, United States

Site Status

Floridian Research

Miami, Florida, United States

Site Status

Behavioral Clinical Research

North Miami, Florida, United States

Site Status

Accel-Orange City

Orange City, Florida, United States

Site Status

CNS Health Care Orlando

Orlando, Florida, United States

Site Status

Complete Health Research

Ormond Beach, Florida, United States

Site Status

Oveido Medical Research

Oviedo, Florida, United States

Site Status

Santos Research Center

Tampa, Florida, United States

Site Status

VICIS Clinical Research, Inc

Tampa, Florida, United States

Site Status

Palm Beach Research

West Palm Beach, Florida, United States

Site Status

Conquest Research, LLC

Winter Park, Florida, United States

Site Status

Delricht

Atlanta, Georgia, United States

Site Status

I-Research Atlanta

Decatur, Georgia, United States

Site Status

Alpha Clinical Research Georgia

Johns Creek, Georgia, United States

Site Status

Clin-Edge, LLC

Marietta, Georgia, United States

Site Status

I Research Savannah

Savannah, Georgia, United States

Site Status

Advanced Clinical Research

Meridian, Idaho, United States

Site Status

CIS Research

Wauconda, Illinois, United States

Site Status

Medisphere Medical Research Center

Evansville, Indiana, United States

Site Status

PMG Research Inc

Ames, Iowa, United States

Site Status

Meridian Clinical Research

Sioux City, Iowa, United States

Site Status

Integrated Clinical Trial SVC

West Des Moines, Iowa, United States

Site Status

Alliance For Multispecialty Research

Lexington, Kentucky, United States

Site Status

Louisville Metabolic & Atherosclerosis Research Center

Louisville, Kentucky, United States

Site Status

Delricht Research

Baton Rouge, Louisiana, United States

Site Status

Crescent City Headache and Neurology

Chalmette, Louisiana, United States

Site Status

Delricht

Covington, Louisiana, United States

Site Status

Alliance for Multispecialty Research

New Orleans, Louisiana, United States

Site Status

Delricht-New Orleans

New Orleans, Louisiana, United States

Site Status

Boston Clinical Trials

Boston, Massachusetts, United States

Site Status

BTC of New Bedford

New Bedford, Massachusetts, United States

Site Status

Northeast Medical Research Associates

North Dartmouth, Massachusetts, United States

Site Status

"Medvadis Research Corp, Llc @Boston Paincare Center "

Waltham, Massachusetts, United States

Site Status

MHNI

Ann Arbor, Michigan, United States

Site Status

Minneapolis Clinic of Neurology

Burnsville, Minnesota, United States

Site Status

Delricht

Gulfport, Mississippi, United States

Site Status

Alliance for Multispecialty Research

Kansas City, Missouri, United States

Site Status

Montana Medical Research, Inc

Missoula, Montana, United States

Site Status

Skyline Medical Center, PC CCT Research

Elkhorn, Nebraska, United States

Site Status

Cognitive Clinical Trials, LLC

Fremont, Nebraska, United States

Site Status

Quality Clinical Research, Inc

Omaha, Nebraska, United States

Site Status

Excel Clinical Research

Las Vegas, Nevada, United States

Site Status

Wake Research-Clinical Research Center of Nevada LLC

Las Vegas, Nevada, United States

Site Status

Clinedge LLC

North Las Vegas, Nevada, United States

Site Status

Albuquerque Clinical Trials

Albuquerque, New Mexico, United States

Site Status

Integrative Clinical Trials

Brooklyn, New York, United States

Site Status

SPRI Clinical Trials, LLC

Brooklyn, New York, United States

Site Status

North Suffolk Neurology

Commack, New York, United States

Site Status

Drug Trials America

Hartsdale, New York, United States

Site Status

Central New York Clinical Research

Manlius, New York, United States

Site Status

Upstate Clinical Research Associates

Williamsville, New York, United States

Site Status

PMG Research of Charlotte

Charlotte, North Carolina, United States

Site Status

Onsite Clinical

Charlotte, North Carolina, United States

Site Status

Headache Wellness Center - Greensboro

Greensboro, North Carolina, United States

Site Status

Pharmquest, LLC

Greensboro, North Carolina, United States

Site Status

Peters Medical Research

High Point, North Carolina, United States

Site Status

North Carolina Clinical Research

Raleigh, North Carolina, United States

Site Status

PMG Research, Inc

Raleigh, North Carolina, United States

Site Status

PMG Research of Wilmington, LLC

Wilmington, North Carolina, United States

Site Status

PMG Research Inc

Winston-Salem, North Carolina, United States

Site Status

Plains Clinical Research

South West Fargo, North Dakota, United States

Site Status

CTI Clinical Research Center

Cincinnati, Ohio, United States

Site Status

Aventiv Research

Columbus, Ohio, United States

Site Status

Aventiv Research, Inc

Dublin, Ohio, United States

Site Status

OK Clinical Research

Edmond, Oklahoma, United States

Site Status

Elite Research Network, LLC a Florida LLC

Norman, Oklahoma, United States

Site Status

Hightower Clinical

Oklahoma City, Oklahoma, United States

Site Status

Delricht Research

Tulsa, Oklahoma, United States

Site Status

Tekton Research

Yukon, Oklahoma, United States

Site Status

Suburban Research Associates

Media, Pennsylvania, United States

Site Status

Ocean State Clinical Research Partners

Lincoln, Rhode Island, United States

Site Status

Velocity Clinical Research.- Providence

Warwick, Rhode Island, United States

Site Status

Clinedge LLC - Clinical Trials SSC

Charleston, South Carolina, United States

Site Status

Tribe CR

Greenville, South Carolina, United States

Site Status

Coastal Carolina Research Center Inc

North Charleston, South Carolina, United States

Site Status

Hillcrest Clinical Research

Simpsonville, South Carolina, United States

Site Status

Internal Medicine and Pediatric Associates of Bristol, PC

Bristol, Tennessee, United States

Site Status

New Phase Research & Development

Knoxville, Tennessee, United States

Site Status

Clinical Research Associates, Inc

Nashville, Tennessee, United States

Site Status

Future Search Trials of Neurology

Austin, Texas, United States

Site Status

Premier Family Physicians

Austin, Texas, United States

Site Status

Discoveresearch

Bryan, Texas, United States

Site Status

Future Search Trials of Dallas, LP

Dallas, Texas, United States

Site Status

Cedar Health Research, LLC

Dallas, Texas, United States

Site Status

North Texas Institute of Neurology

Frisco, Texas, United States

Site Status

Epic Clinical Research

Lewisville, Texas, United States

Site Status

DM Clinical Research

Magnolia, Texas, United States

Site Status

Village Health Partners

Plano, Texas, United States

Site Status

Sun Research

San Antonio, Texas, United States

Site Status

DM Clinical Research

Tomball, Texas, United States

Site Status

Advanced Research Institute

Ogden, Utah, United States

Site Status

Charlottesville Medical Research

Charlottesville, Virginia, United States

Site Status

Alliance For Multispecialty Research

Norfolk, Virginia, United States

Site Status

Tidewater Integrated Medical Research

Virginia Beach, Virginia, United States

Site Status

Northwest Clinical Research Center

Bellevue, Washington, United States

Site Status

Seattle Womens

Seattle, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

STS101-007

Identifier Type: -

Identifier Source: org_study_id