Motivational, Affective and Performance Effects of Caffeine Supplementation

NCT ID: NCT06321861

Last Updated: 2024-03-20

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-19
• Study Completion Date: 2024-05-01

Brief Summary

The main objective of the study is to evaluate the influence of caffeine intake on participants' energetic arousal, affect, motivation to achieve a training goal, satisfaction with training, and the sense of agency during training. Consequently, participants will engage in three sessions: caffeine, placebo, and no substance (in counterbalanced order). During each session, their affective and motivational states will be assessed, along with the performance of a standardized physical exercise test. The investigators hypothesize that participants who consume caffeine (caffeine condition) will exhibit higher levels of energy and motivation compared to the other two groups. Additionally, they are expected to experience greater optimism and expectancy regarding their training goals and achieve better results in the physical exercise test.

A secondary aim of the study is to examine the impact of genetic variability on motivational and affective states of participants, as well as their performance in the physical exercise test after caffeine. The investigators will assess the CYP1A2 (-163C > A, rs762551; characterized such as "fast" (AA genotype) and "slow" caffeine metabolizers (C-carriers)) and ADORA2A (1976T > C; rs5751876; characterized by "high" (TT genotype) or "low" sensitivity to caffeine (C-carriers)).

Detailed Description

Before participating in the study, participants will answer questions regarding their consumption of caffeinated beverages and the frequency of their workouts. They will also complete the Extreme Personality Scale measuring the tendency to pursue goals single-mindedly. Subsequently, they will be qualified for the study based on the questionnaire results and a brief interview.

The study will involve the manipulation of energization through the administration of caffeine. Participants will take part in a randomized, crossover, double-blind study, where they will perform three identical training sessions after consuming: a) caffeine at a dose of 3 mg/kg of body weight; b) a placebo; and c) under control conditions (i.e., without substance administration). Capsule consumption will occur 60 minutes before the start of the training. Caffeine and placebo capsules will not differ in size, shape, color, and taste.

As the effectiveness of caffeine use depends on the CYP1A2 (rs762551) and ADORA2 (rs5751876) gene polymorphisms, the study will also genotype these genes. The first gene is responsible for the rate of caffeine metabolism, determining whether people metabolize caffeine "fast" or "slow." The ADORA2A gene, encoding the adenosine A2A receptor, influences how "sensitive" people are to caffeine. DNA isolates obtained from oral epithelial cells collected from participants by qualified medical personnel will constitute the research material. Oral epithelial swabs will be collected directly from the participants into sterile tubes.

Before and after substance intake (and additionally after the exercise test) participants will assess their arousal using the University of Wales Institute of Science and Technology Mood Adjective Checklist. Additionally, after substance intake and before exercise, participants will answer questions about motivation, affect and expectancy regarding training. Subsequently, participants will undergo training, taking the form of a supervised standardized exercise test. After exercise, participants will assess their satisfaction and feelings after completing the training.

Conditions

Caffeine; Affect; Goals

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: TRIPLE

Study Groups

Caffeine

Participants will take a caffeine pill (3mg/kg of body mass) 60 minutes before the physical exercise test.

Group Type: EXPERIMENTAL

Caffeine

Intervention Type: DIETARY_SUPPLEMENT

Participants will take one caffeine pill. The dose of caffeine will be calculated based on participants' body mass (3mg/kg body mass). Caffeine will be provided in capsules containing the individual amount of caffeine and will be administered orally 60 min before the onset of the exercise protocol.

Placebo

Participants will take a placebo pill 60 minutes before the physical exercise test.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Participants will take one pill with no caffeine in it. The manufacturer of the caffeine capsules will also prepare identical placebo capsules filled out with a microcrystalline cellulose. Placebo will be administered orally 60 min before the onset of the exercise protocol.

No substance

Participants receive no pills in this condition before the physical exercise test.

Group Type: OTHER

No substance

Intervention Type: OTHER

Participants will take no substance. They will just wait 60 minutes and then engage in the exercise protocol.

Interventions

Caffeine

Participants will take one caffeine pill. The dose of caffeine will be calculated based on participants' body mass (3mg/kg body mass). Caffeine will be provided in capsules containing the individual amount of caffeine and will be administered orally 60 min before the onset of the exercise protocol.

Intervention Type: DIETARY_SUPPLEMENT

Placebo

Participants will take one pill with no caffeine in it. The manufacturer of the caffeine capsules will also prepare identical placebo capsules filled out with a microcrystalline cellulose. Placebo will be administered orally 60 min before the onset of the exercise protocol.

Intervention Type: DIETARY_SUPPLEMENT

No substance

Participants will take no substance. They will just wait 60 minutes and then engage in the exercise protocol.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age 18-30 years
• Caffeine consumption
• Engagement in physical activity.

Exclusion Criteria

• Diagnosed cardiovascular, metabolic, gastrointestinal, or neurological diseases
• Taking medications or supplements that may affect test results
• Tobacco smoking
• Pregnancy
• Potential allergy to caffeine.

Participation in the study will be preceded by completing a health questionnaire and providing written consent. Additionally, exclusion from the study will occur upon the explicit request of the participant.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Jerzy Kukuczka Academy of Physical Education in Katowice

OTHER

Sponsor Role: collaborator

University School of Physical Education, Krakow, Poland

OTHER

Sponsor Role: collaborator

Jagiellonian University

OTHER

Sponsor Role: lead

Responsible Party

Ewa Szumowska

Assistant

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ewa Szumowska

Role: PRINCIPAL_INVESTIGATOR

Jagiellonian University

Locations

The Jerzy Kukuczka Academy of Physical Education in Katowice

Katowice, , Poland

Site Status: RECRUITING

Countries

Poland

Central Contacts

Ewa Szumowska

Role: CONTACT

ewa.szumowska@uj.edu.pl

+48504756394

Aleksandra Filip-Stachnik

Role: CONTACT

a.filip@awf.katowice.pl

Facility Contacts

Aleksandra Filip-Stachnik

Role: primary

References

Matthews G; Jones DM, Chamberlain AG. Refining the measurement of mood: The UWIST mood adjective checklist. British Journal of Psychology, 1990, 81(1): 17-42.

Reference Type: BACKGROUND

Szumowska E, Molinario E, Jaśko K, Hudiyana J, Firdiani NF, Penrod J, Jaume LC, Leander NP, Kreienkamp J, Agostini M, Gruszka A, Szumska I, Stelmaszyńska D, Gola M, Altungy P, Gómez Á, Cacek J, & Kruglanski AW (2023). The Extreme Personality: Individual Differences in Proneness to Motivational Imbalance. Manuscript submitted for publication.

Reference Type: BACKGROUND

Other Identifiers

Caffeine_motivation

Identifier Type: -

Identifier Source: org_study_id