Polytrauma and Resuscitation Impact on Innate Immunity

NCT ID: NCT06314841

Last Updated: 2024-03-18

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 62 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-06-01
• Study Completion Date: 2022-01-01

Brief Summary

Major trauma can lead to a dysregulated response to secondary infection. Severe injuries are accompanied by pro- and antiinflammatory changes that affect both adaptive and innate immunity. In this study we aim to assess cellular immuno-competence early during treatment in an attempt to identify signs of immuno-suppression.

Detailed Description

Polytrauma represents one of the most challenging critical conditions for caretakers worldwide and involves multiple damages of different anatomical regions. Severe traumatic injuries are among the primary causes of death among young people under the age of 45 and half of them are due to uncontrollable bleeding. In the acute injury phase of trauma, severe blood loss is often accompanied by biochemical, cellular and physiological dysfunctions leading to an inflammatory response, infections and in some cases coagulopathy. We aim to identify immuno-suppression by analyzing phagocytic capacity, leukocyte subsets, surface molecule expression and extracellular vesicles in the peripheral blood of severly injured patients.

Conditions

Wounds and Injuries

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Age > 18
• Injury Severity Score (ISS) > 15
• Incident to admission time < 3h

Exclusion Criteria

• Preexisting condition
• Pregnancy or breastfeeding
• Diabetes
• Coronary Heart Disease
• Intake of antiphlogistic medication
• Neoplasm

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

AUVA

OTHER

Sponsor Role: collaborator

Ludwig Boltzmann Gesellschaft

OTHER

Sponsor Role: lead

Responsible Party

Gerhard Fritsch

Priv.-Doz., Prim., Dr.med.univ

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Susanne Drechsler, DVM

Role: STUDY_CHAIR

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology

Marcin Osuchowski, DVM

Role: STUDY_CHAIR

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology

Heinz Steltzer, MD, Prof.

Role: STUDY_CHAIR

Trauma Center Vienna, Meidling

Locations

Trauma Center Vienna, Meidling

Vienna, , Austria

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Trauma Research Center

Vienna, , Austria

Trauma Center Vienna, Lorenz Böhler

Vienna, , Austria

Countries

Austria

Other Identifiers

LBG-AUVA

Identifier Type: -

Identifier Source: org_study_id