Inflammation and Infection in Trauma, Role in Posttraumatic Complications

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

380 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-03-31

Study Completion Date

2005-09-30

Brief Summary

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The purpose of this study is to investigate the relationship between trauma, the immune system, biochemical changes in the first 24 h and subsequent complications and mortality

Detailed Description

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The immune system plays a role in the development of complications after severe trauma, but we do not know how. Equally, biochemical changes measured in the blood after trauma (eg. bloodglucose, GC-globulin, coagulation parameters etc.) may predict the prognosis and the degree of complcations. Two significant complications are infection and organ failure, which may prolong hospitalisation and increase mortality.

In the study we collected samples from blood and body surfaces to determine changes in cytokines, biochemistry, bacterial flora, and subsequent complications. We compare the changes in between groups of the cohort.

Conditions

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Trauma

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Clinical suspicion of multiple trauma
* Age \>/= 18 years
* Direct referral from scene of accident

Exclusion Criteria

* Major burn injury
* HIV positiv
* Pregnancy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Jakob Stensballe, MD

Role: STUDY_CHAIR

Rigshospitalet, Denmark

Locations

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Rigshospitalet, Copenhagen University Hospital

Dk-2100 Copenhagen, , Denmark

Site Status

Countries

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Denmark

References

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Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg. 2011 Aug;254(2):194-200. doi: 10.1097/SLA.0b013e318226113d.

Reference Type DERIVED

PMID: 21772125 (View on PubMed)

Other Identifiers

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KF 01-160/02 Main

Identifier Type: -

Identifier Source: org_study_id