Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
40 participants
OBSERVATIONAL
2010-06-30
2011-06-30
Brief Summary
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Detailed Description
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Severe poly trauma involves complex injuries that consist of multiple pathological mechanisms involving cytotoxic, oxidation stress and immune-endocrine. The complexity of the pathological physiology and biochemistry process are determined not only by the initial mechanical assault, but also by secondary processes including abnormality of inflammation regulation, ischemia, anoxia, free-radical formation, and immune dysfunction that occur over hours and days following the injury. For the clinical perspective, one of the key difficulties is to identify the most at-risk patients who could develop multiple organ failures and consequently death.
This study aims to establish the dynamics of NMR-based metabonomics fingerprinting of severe multi-trauma patients in order to provide a possible multiple organs failure (MOF) or death event prediction.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Poly trauma
20 Patients suffering from poly trauma who meet inclusion criteria would be recruited
No interventions assigned to this group
Healthy control
20 healthy volunteers would be recruited to obtain basal metabonomics fingerprinting
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Poly trauma
* Injury Severity Score (ISS)\>16 and Acute Physiology And Chronic Health Evaluation(APACHE)II\>10
Exclusion Criteria
* Pregnancy
18 Years
50 Years
ALL
Yes
Sponsors
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Sichuan Academy of Medical Sciences
OTHER
Responsible Party
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Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital
Principal Investigators
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Hua Jiang, M.D
Role: STUDY_CHAIR
Sichuan Academy of Medical Sciences
Zhi-Yuan Zhou, M.S
Role: PRINCIPAL_INVESTIGATOR
Sichuan Academy of Medical Sciences
Ming-Wei Sun, M.D
Role: PRINCIPAL_INVESTIGATOR
Sichuan Academy of Medical Sciences
Locations
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Sichuan Academy of Medical Sciences, Sichuan Provincial Hospital, Dept. Trauma Surgery
Chengdu, Sichuan, China
Countries
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Other Identifiers
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META-LAB-10-07-003C-02
Identifier Type: -
Identifier Source: org_study_id
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