Early Vascular Wall Changes by Magnetic Resonance Imaging (MRI) in Metabolic Syndrome Versus Metabolically Normal Pre-Menopausal Women: A Pilot Study

NCT ID: NCT01068535

Last Updated: 2012-09-14

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 43 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-05-31
• Study Completion Date: 2013-07-31

Brief Summary

The purpose of this study is to compare the vascular permeability of blood vessel walls (of the carotid artery) in pre-menopausal women who have metabolic syndrome (syndrome of having at least 3/5 following features- increased abdominal fat, low good cholesterol (HDL-C), elevated fasting blood fats (triglycerides), elevated blood pressure, an elevated fasting glucose) versus those women who are normal weight and with normal cholesterol, blood fats, blood pressure, and blood sugar. We are using a novel technology to measure vascular permeability known as dynamic contrast enhancement magnetic resonance imaging (DCE-MRI). The primary variable is ktrans ratio which is a mathematically derived quantity obtained from DCE-MRI. We are trying to identify novel markers of early atherosclerosis in young women.

Detailed Description

This study involves a phone screen & 2 study visits:

• Screening visit, which includes a quick finger stick cholesterol, glucose, triglycerides test (cholestech) to determine qualification, waist measurement, weight. Results are provided regardless of qualification. If the volunteer qualifies, a full blood draw (approximately 45cc or 3 Tablespoons) will occur. A snack is provided once blood is drawn. Additional study visit procedures include a medical history questionnaire including menstrual history, height & weight measurement, vital signs, and waist & hip measurements. This study lasts up to 90 minutes.
• MRI visit (to occur within a week of screening visit) occurs once serum pregnancy & creatinine results are received & only if approved to continue by P.I. (e.g. negative serum pregnancy and eGFR>60). An IV catheter is placed in the antecubital vein to administer an injection of (gadolinium) contrast medium. A coil is placed on each side of the subject's neck while laying flat on a bench, with her upper body inside the MRI scanner. The entire MRI procedure takes approximately 60 minutes.

Conditions

Metabolic Syndrome

Keywords

metabolic syndrome; MetS; premenopausal women; vascular risk; atherosclerosis detection

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Women with Metabolic Syndrome

Pre-menopausal women with Metabolic Syndrome

Age 35-50 and any 3 of the following:

Fasting triglycerides ≥ 150 mg/dL, Waist measurement ≥ 35 inches, HDL < 50mg/dL, Fasting glucose ≥ 100mg/dL but <126mg/dL or Blood pressure ≥ 130/85 or taking medication to treat high blood pressure.

No interventions assigned to this group

Non-Metabolic Syndrome (healthy) women

Non-Metabolic syndrome pre-menopausal women age 35-50

• Body Mass Index ≤ 25
• Regular menstrual cycles (occur every 24-35 days)
• Fasting glucose < 100mg/dL
• HDL-C ≥ 50mg/dL
• Waist measurement ≤ 35 inches
• Fasting triglycerides < 150mg/dL

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Pre-menopausal women (age 35-50)

• still having menstrual periods

Exclusion Criteria

• History of diabetes mellitus
• History of cardiovascular disease (peripheral vascular disease, coronary artery disease, cerebrovascular disease)
• Serum creatinine >1.2 mg/dL (eGFR <60 ml/min.)
• Active rheumatologic disease
• Use of hormonal contraception*
• Pregnant or planning a pregnancy within the next 3 months
• Fasting triglycerides ≥ 500 mg/dL
• Fasting LDL-C ≥ 190 mg/dL
• Currently taking lipid lowering medications*
• Currently taking vaso-active (blood pressure) medications*
• Hypertension: SBP ≥ 140 and or DBP ≥90 mm Hg
• Chronic use of aspirin (prn use is allowed)
• Chronic use of non-steroidal anti-inflammatory medications (prn use is allowed)
• Tobacco use within 3 months of starting study
• Participation in another clinical trial within the last 30 days

• History of claustrophobia
• History of decrease in kidney function (eGFR <60 ml/min.)
• History of reaction to a contrast medium or dye used for an MRI, CT Scan, or X-ray
• History of significant anemia or other blood disease
• History of seizures
• MRI-incompatible metal such as internal metal hardware or devices * Drugs within the following classifications are exclusionary: Antilipemics, antilipidemics, beta blockers, ACE inhibitors, angiotensin receptor blockers, diuretics, calcium channel blockers, alpha blockers, nitrates, and all hormonal contraceptives

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Washington

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Pathmaja Paramsothy, M.D.,M.S.

Role: PRINCIPAL_INVESTIGATOR

University of Washington

Locations

Harborview/University of Washington

Seattle, Washington, United States

Countries

United States

Other Identifiers

35352-A

Identifier Type: -

Identifier Source: org_study_id