Predicting the Metabolic Biomarkers Associated With Injury in Athletes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-20

Study Completion Date

2027-12-31

Brief Summary

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For elite athletes, sports injuries significantly impede the further enhancement of their competitive performance. Consequently, the significance of preventing, detecting, and addressing potential injury issues has become increasingly critical. Currently, the comprehensive evaluation of athletes' physical function and condition primarily depends on a range of physiological, biochemical, and immunological indicators. However, these methods have progressively exposed their limitations. As an advanced bioinformatics technology, omics research demonstrates unique advantages. By leveraging multi-omics research and analysis, it is possible to more accurately observe the physiological and biochemical changes that athletes undergo during training and competition, as well as their regulatory mechanisms. This approach can provide practical data, identify biomarkers that can warn of potential injuries, and offer precise guidance for training monitoring and injury prevention. It also provides a foundation for developing diverse, precise, and personalized sports programs and rehabilitation plans.

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Detailed Description

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Investigators will collect fasting venous blood. White blood cell count, red blood cell count, erythrocyte specific volume, hemoglobin, C-reactive protein, procalcitonin, erythrocyte sediment rate, lactic acid,creatine kinase, liver function indicators, blood urea, blood creatinine, blood uric acid, blood testosterone, blood cortisol, immunoglobulin (IgG, IgA, IgM) and ferritin levels were measured. The levels of IL-2, IL-6, IL-1β and TNF-α were determined by ELISA. Blood samples were purified and analyzed by proteomics, metabolomics and lipidomics methods. Urine and stool samples were collected and analyzed by multi-omics method.

Conditions

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Sports Medicine

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Acute Injury athletes

Athletes in sports, due to sudden external force or improper operation, resulting in body tissue damage in a short period of time. This injury usually has sudden and distinct traumatic features, and common types include:

1. Sprain: Joint due to excessive torsion or stretching, resulting in ligament damage.
2. Strain: An injury to a muscle or tendon caused by excessive stretching or contraction.
3. Contusion: A direct impact on the body part causes damage to the subcutaneous tissue, which may be accompanied by bruising.
4. Fracture: The bone is broken due to external force.
5. Dislocation: The joint is removed from its normal position due to external forces.

No interventions assigned to this group

Healthy athletes

athletes with no acute injury in the last 3 months

No interventions assigned to this group

Healthy

Healthy non-athlete population

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Age： Athletes 12-30 years old
2. Acute injury during exercise: such as muscle, sprain, contusion, torn ligament, dislocation, fracture.

Exclusion Criteria

1. Athletes with serious cardio-cerebrovascular disease and abnormal liver and kidney function
2. Recent use of drugs or supplements that affect metabolism.
3. Pregnancy, lactation or special conditions that may affect metabolism.

Minimum Eligible Age

12 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes