Research on the Application and Mechanism of New Biological Probes in Biomedicine

NCT ID: NCT04977739

Last Updated: 2022-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

737 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-03

Study Completion Date

2022-07-25

Brief Summary

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Fluorescence is one of the most commonly used research and detection techniques in the field of biomedical science. The characteristics of fluorescent probe directly affect the performance and application of fluorescence analysis and imaging. Aggregation-Caused Quenching has limited the application of traditional fluorescent probes to some extent. This project intends to systematically evaluate the detection efficiency of new methods through the detection of biomarkers in clinical samples and the comparison with the detection methods of traditional biomarkers, so as to provide theoretical and experimental basis for the establishment of fast and simple biomarker detection technologies with new biological probes.

Detailed Description

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Conditions

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Tumors Cardiovascular Diseases Respiratory System Diseases Digestive System Diseases Endocrine System Diseases Metabolic Diseases Immune System Diseases Urinary System Diseases Nervous System Diseases Blood Diseases Infectious Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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those with a condition

No intervention

Intervention Type DIAGNOSTIC_TEST

No intervention

those without a condition

No intervention

Intervention Type DIAGNOSTIC_TEST

No intervention

Interventions

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No intervention

No intervention

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Sign the informed consent form voluntarily.
* Age 18-70 years old.
* High expression (positive) group: The results of multiple laboratory tests indicate that the marker is higher than the normal range.
* Low expression (negative) healthy volunteer group: those with no underlying diseases and no abnormalities in the physical examination.
* Have routine examination to check the remaining body fluid samples, and the body fluid samples are not contaminated.

Exclusion Criteria

* Accompanied by other inflammations.
* The data of the subject is not complete, or the collection of cases is incomplete due to other reasons.
* The researcher judged that it was not suitable to participate in this research.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nanfang Hospital, Southern Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bo Situ

Role: STUDY_DIRECTOR

Nanfang Hospital, Southern Medical University

Locations

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Nanfang Hospital

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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NFEC-2021-007

Identifier Type: -

Identifier Source: org_study_id

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