Wound Vitality Markers in Forensic Pathology

NCT ID: NCT02892526

Last Updated: 2016-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

57 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-12-31

Study Completion Date

2016-12-31

Brief Summary

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The purpose is to determine intrinsic properties of various immunohistochemical markers (FVIIIra, CD15, CD30, tryptase, TNFα, IL-1β, TGFα et TGFβ1) for diagnosis of vital wound, alone and in association (evaluation of sensibility with surgery wounds and evaluation of specificity with post-mortem wounds).

Secondary purposes are to measure the minimum time to obtain a positive labeling in vital wounds, and to evaluate inter-observer reproducibility of vitality diagnosis with different markers. Expression of microRNA miR 9, miR 21 et miR 198 will be also studied.

Detailed Description

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Conditions

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Wound

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Vital wounds

from abdominoplasty of alive persons

Abdominoplasty with exeresis of cutaneous tissue

Intervention Type OTHER

Post-mortem wounds

from autopsy of deceased persons

Collection of cutaneous tissue

Intervention Type OTHER

Interventions

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Abdominoplasty with exeresis of cutaneous tissue

Intervention Type OTHER

Collection of cutaneous tissue

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Alive persons:

\- Abdominoplasty

Deceased persons:

\- Medico-scientific autopsy for diagnosis

Exclusion Criteria

Alive persons:

* Fragmented sample with non-visible banks
* Cutaneous pathology

Deceased persons:

* Persons under protection
* Medico-legal obstacle
* Cutaneous pathology
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Laurent MARTRILLE

Role: PRINCIPAL_INVESTIGATOR

Service de Médecine Légale - CHRU de Nancy

Locations

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CHRU Nancy

Nancy, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Laurent MARTRILLE

Role: CONTACT

Other Identifiers

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2012/CPRC/PLAIES VITALES/MART

Identifier Type: -

Identifier Source: org_study_id

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