Provocative Tests for HFpEF

NCT ID: NCT06309550

Last Updated: 2025-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-10

Study Completion Date

2028-03-31

Brief Summary

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Diagnosing heart failure with preserved ejection fraction (HFpEF) in patients complaining exertional breathlessness can be challenging: diagnostic algorithms and scores have low sensitivity, and ageing-associated comorbidities can complicate the interpretation of symptoms. Thus, exercise right heart catheterization (RHC) or invasive cardiopulmonary exercise test (iCPET) have been advocated as gold-standard methods for HFpEF diagnosis. However, exercise RHC and iCPET are still not widely standardized methods, with results mainly coming from US cohorts (that may differ from Italian cohorts), and other provocative tests (e.g. non-invasive CPET, passive leg raising) may offer complementary diagnostic information.

Detailed Description

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Conditions

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Heart Failure With Preserved Ejection Fraction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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exercise test

exercise test

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* dyspnea

Exclusion Criteria

* known HFpEF
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Istituto Auxologico Italiano

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ospedale San Luca IRCCS Istituto Auxologico Italiano

Milan, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Sergio Caravita, MD, PhD

Role: CONTACT

+39 02 619112930

Facility Contacts

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Sergio Caravita, MD, PhD

Role: primary

+39 02 61911 2930

Other Identifiers

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09W002

Identifier Type: -

Identifier Source: org_study_id

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