Classification of Heart Failure With Preserved Ejection Fraction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

514 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-01

Study Completion Date

2019-05-21

Brief Summary

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The purpose of this study is to create a classification system for the heterogenous disorder of heart failure with preserved ejection fraction (HFpEF).

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Detailed Description

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Patients with HFpEF are a heterogeneous group with varying etiology and pathophysiology, which may play a large role in the difficulty in managing these patients and enrolling them in clinical trials. A major advance in the care of patients with HFpEF would be a classification system based on etiology, pathophysiology, and/or genetic factors as well as machine learning analyses. The ultimate goal of this study is to demonstrate that it is possible to better classify patients with HFpEF based on etiologic, pathophysiologic, and genetic differences between patients. If successful, this study could lead to: (1) novel risk estimation in patients with HFpEF and (2) more fruitful clinical trials based on targeting specific subsets of HFpEF.

Conditions

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Heart Failure With Preserved Ejection Fraction Diastolic Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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HFpEF

HFpEF cohort (observational study)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age \> 21 years
* Signs or symptoms of congestive heart failure
* Left ventricular ejection fraction \> 50%

Exclusion Criteria

* Severe valvular heart disease
* History of cardiac transplantation
* Prior history of heart failure associated with left ventricular ejection fraction \< 35%

Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No