Staging Heart Failure With Preserved Ejection Fraction

NCT ID: NCT06931015

Last Updated: 2025-04-20

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 700 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-04-20
• Study Completion Date: 2028-12-13

Brief Summary

Heart failure with preserved ejection fraction (HFpEF) is considered a systemic condition in which the prevalence of cardiovascular, metabolic, pulmonary and renal conditions determine the extent of cardiac involvement. Numerous attempts have been made to phenotype HFpEF, but patients still lack a clinically and/or prognostically relevant approach.

Progressive cardiac deterioration in HFpEF appears to be associated with a worse prognosis. However, no attempt has been made to classify the extent of cardiac involvement in HFpEF. Investigators proposed the concept of HFpEF staging according to the extent of cardiac involvement identified by transthoracic echocardiography: Stage 1: isolated left ventricular involvement; Stage 2: left atrial myopathy; Stage 3: pulmonary vasculature involvement; and Stage 4: right chambers involvement.

The study aims to investigate the associations between the proposed stages and clinical outcomes in HFpEF patients.

Detailed Description

HFpEF is a major global public health concern due to increasing incidence and prevalence, poor prognosis and limited availability of disease-modifying therapy. The management of HFpEF and the development of novel treatments are complicated due to the heterogeneous nature of the disease, which presents multiple clinical phenotypes. Each is characterised by a unique combination of cardiac and non-cardiac comorbidities such as hypertension, obesity, type 2 diabetes, chronic kidney disease, chronic obstructive pulmonary disease and others. Numerous attempts have been made to phenotype HFpEF, but patients still lack a clinically and/or prognostically relevant approach.

Looking beyond the phenotypes, HFpEF is considered a systemic condition in which the prevalence of cardiovascular, metabolic, pulmonary and renal conditions determine the extent of cardiac involvement. Progressive cardiac deterioration in HFpEF appears to be associated with a worse prognosis. However, no attempt has been made to classify the extent of cardiac involvement in HFpEF.

Investigators proposed the concept of HFpEF staging according to the extent of cardiac involvement identified by transthoracic echocardiography (TTE), which includes four stages: Stage 1: isolated left ventricular involvement; Stage 2: left atrial myopathy; Stage 3: pulmonary vasculature involvement; and Stage 4: right chambers involvement. Emerging data suggest that every subsequent cardiac chamber deterioration could be of prognostic value.

The study aims to investigate the associations between the proposed stages and clinical outcomes in HFpEF patients.

Conditions

Heart Failure With Preserved Ejection Fraction; Cardiovascular Diseases; Heart Failure

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

HFpEF Stage 1: Isolated left ventricle involvement

Established if patients meet the criteria of Stage 1, according to the proposed classification, which are:

• LVMI >115 g/m2 in men/ and >95 g/m2 in women or
• Relative wall thickness (RWT) >0.42 or
• Elevated LV filling pressures at rest (E/e' >9)

doi.org/10.15420/ecr.2024.31

No interventions

Intervention Type: OTHER

No interventions

HFpEF Stage 2: Left atrial myopathy

Stage 1 criteria, plus:

• LAVI >34 ml/m2, if sinus rhythm or
• AF

No interventions

Intervention Type: OTHER

No interventions

HFpEF Stage 3: Pulmonary vasculature involvement

Stage 1-2 criteria, plus:

• Pulmonary artery systolic pressure (PASP) >35 mmHg and/or
• Tricuspid regurgitation (TR) velocity >2.8 m/s

No interventions

Intervention Type: OTHER

No interventions

HFpEF Stage 4: Right chambers involvement

Stage 1-3 criteria, plus:

• Fractional area change (FAC) <35% or
• S' <9.5 cm/s and/or
• Tricuspid annular plane systolic excursion (TAPSE) <17 mm and/or
• Right atria (RA) volume index (>39 ml/m2 in men/ >33 ml/m2 for women)

No interventions

Intervention Type: OTHER

No interventions

Interventions

No interventions

No interventions

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. ≥ 40 years of age, male and female

2. Heart failure symptoms, New York Heart Association (NYHA) II- III

3. Left ventricular ejection fraction (LVEF) > 50% documented by echocardiography at screening

4. One of the following scenarios:

A) At screening, N-terminal pro-B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (sinus rhythm) or ≥600 pg/mL (if AF) and echocardiographic criteria see #5

B) Previously confirmed HFpEF in combination with a history of hospitalization for HFpEF decompensation >30 days before screening defined as the presence of dyspnea and 2 of the following:

• Rales on chest auscultation or sings of congestion on X-ray/CT scan
• Peripheral Oedema
• Elevated NT-proBNP ≥300 pg/mL (sinus rhythm) or ≥600 pg/mL (if AF)

5. Structural and/or functional abnormalities of heart, at least one of the following:

• Left atrial volume index (LAVI) >34 mL/m2 (if AF >40 mL/m2)
• Left ventricular mass index (LVMI) =115 g/m2 for males and =95 g/m2 for females
• Relative wall thickness > 0.42
• E/e' ratio at rest >9

6. Stable doses of oral loop diuretics, if prescribed

7. Ability to provide informed consent

Exclusion Criteria

• Any prior measurements of LVEF <50%
• Established diagnosis of infiltrative (amyloidosis etc.), hypertrophic cardiomyopathy, muscular dystrophies, complex congenital heart disease, active myocarditis or pericardial constriction
• Planned interventions, including major cardiac surgery, percutaneous coronary intervention (PCI), transcatheter aortic valve implantation (TAVI), or implantation of cardiac resynchronization therapy
• Elective PCI or atrial fibrillation ablation within 30 days before visit
• Moderate and severe valve stenosis and more than mild primary valve regurgitation
• Acute myocardial infarction in the last 3 months, cardiac surgery, pulmonary embolism or cerebrovascular accident within the last six months
• Candidates for heart transplantation
• Secondary hypertension
• Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease
• Any active cancer
• Infective endocarditis
• Alcoholic cirrhosis
• End-stage kidney disease
• Any other condition judged by the investigator that could account for heart failure symptoms and signs (e.g., anaemia, hypothyroidism).

• Minimum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

I.M. Sechenov First Moscow State Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Anastasia Shchendrygina

Role: PRINCIPAL_INVESTIGATOR

Sechenov University

Locations

A Shchendrygina

Moscow, , Russia

Countries

Russia

Central Contacts

Anastasia Shchendrygina

Role: CONTACT

a.shchendrygina@gmail.com

+79262309207

Svetlana Rachina

Role: CONTACT

rachina_s_a@staff.sechenov.ru

Facility Contacts

Anastasia Shchendrygina

Role: primary

a.shchendrygina@gmail.com

89262309207

Related Links

https://www.ecrjournal.com/articles/staging-heart-failure-preserved-ejection-fraction-assessing-cardiac-chamber-involvement?language_content_entity=en

The publication which define the concept of Staging Heart Failure with Preserved Ejection Fraction by Assessing Cardiac Chamber Involvement

Other Identifiers

05-22

Identifier Type: -

Identifier Source: org_study_id