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Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients

NCT ID: NCT02946476

Last Updated: 2016-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2314 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-11-30

Study Completion Date

2014-12-31

Brief Summary

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To better understand the public health prognostic impact of noncardiac chronic illnesses, we explored the attributable risk of noncardiac comorbidities on outcomes between heart failure patients with reduced ejection fraction (HFREF) and heart failure patients with preserved ejection fraction (HFpEF) in a large contemporary heart failure (HF) population The adjusted hazard ratio (HR) and the population attributable risk were used to compare the contributions of 15 noncardiac comorbidities to adverse outcome. The comorbidities that contributed to high attributable risk were: anemia, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and peripheral artery disease. These findings were similar for HFrEF and HFpEF groups. Interaction analysis confirmed similar results.

Detailed Description

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Conditions

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Heart Failure, Diastolic Heart Failure, Systolic

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Study Groups

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HFrEF

patients with heart failure and reduced ejection fraction

prognostic impact of non cardiac comorbidities

Intervention Type OTHER

HFpEF

patients with heart failure and preserved ejection fraction

prognostic impact of non cardiac comorbidities

Intervention Type OTHER

Interventions

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prognostic impact of non cardiac comorbidities

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All consecutive heart failure patients with left ventricular ejction fraction available before or within 3 months from the index visit

Exclusion Criteria

* We excluded all patients who had severe primary left-sided valvular disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ospedale Maggiore Di Trieste

OTHER

Sponsor Role lead

Responsible Party

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Annamaria Iorio

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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OMTrieste

Identifier Type: -

Identifier Source: org_study_id