Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
60 participants
OBSERVATIONAL
2024-10-31
2029-12-31
Brief Summary
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Chemoreflex sensitivity accounts for the ventilatory responses to a variety of chemical stimuli, including carbon dioxide produced by the organism during exercise. Chemoreflex sensitivity can be augmented in heart failure with reduced left ventricular ejection fraction, and an increased chemoreflex sensitivity has been linked to symptoms, neurohumoral activation, breathing disturbances, and adverse prognosis.
However, the clinical correlates and implications of chemoreflex sensitivity in HFpEF have not been accurately studied.
We aim to characterize chemoreflex sensitivity in patients with a diagnosis of HFpEF, and to correlate chemoreflex sensitivity with clinical and hemodynamic characteristics.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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HFpEF
symptomatic patients with heart failure with preserved ejection fraction
chemoreflex evaluation
the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants
asymptomatic PH-LHD
asymptomatic left ventricular diastolic dysfunction with echocardiographic signs of pulmonary hypertension
chemoreflex evaluation
the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants
healthy volonteers
chemoreflex evaluation
the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants
Interventions
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chemoreflex evaluation
the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants
Eligibility Criteria
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Inclusion Criteria
* diagnosis of asymptomatic left ventricular diastolic dysfunction with echocardiographic signs of PH (group 2)
* healthy volunteers (group 3)
Exclusion Criteria
ALL
Yes
Sponsors
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Istituto Auxologico Italiano
OTHER
Responsible Party
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Locations
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Ospedale San Luca IRCCS Istituto Auxologico Italiano
Milan, , Italy
Countries
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Central Contacts
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Other Identifiers
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09C830
Identifier Type: -
Identifier Source: org_study_id
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