Noninvasive Modulation of Chronic Neuropathic Pain

NCT ID: NCT06249724

Last Updated: 2025-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE1/PHASE2

Study Classification

INTERVENTIONAL

Study Start Date

2024-02-10

Study Completion Date

2024-02-10

Brief Summary

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This study will apply low-intensity transcranial focused ultrasound to dorsal root ganglia in patients with chronic neuropathic pain. The target will be validated using magnetic resonance imaging. The stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled cross-over trial. The level of pain will be evaluated using the Numerical Rating Scale (NSR-11) and the Patient-Reported Outcomes Measurement Information System (PROMIS) numerical rating scales of pain.

Detailed Description

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Conditions

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Neuropathic Pain Chronic Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Active stimulation

Low-intensity focused ultrasound stimulation of dorsal root ganglion involved in pain conduction

Group Type ACTIVE_COMPARATOR

Active stimulation using low-frequency ultrasonic transducer

Intervention Type DEVICE

The ultrasonic transducer delivers focused low-intensity ultrasound stimulation

Sham stimulation

Zero-intensity focused ultrasound stimulation of dorsal root ganglion involved in pain conduction

Group Type SHAM_COMPARATOR

Sham stimulation using low-frequency ultrasonic transducer

Intervention Type DEVICE

The ultrasonic transducer delivers focused zero-intensity ultrasound stimulation

Interventions

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Active stimulation using low-frequency ultrasonic transducer

The ultrasonic transducer delivers focused low-intensity ultrasound stimulation

Intervention Type DEVICE

Sham stimulation using low-frequency ultrasonic transducer

The ultrasonic transducer delivers focused zero-intensity ultrasound stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Primary diagnosis of chronic pain
* Moderate-to-severe chronic pain lasting at least 2 months
* Stated willingness to comply with all study procedures and avoid changes to current treatments (medications, physical therapy, cognitive behavioral therapy) for the duration of the study
* For females of reproductive potential: negative pregnancy test or use of highly effective contraception for at least 1 month prior to baseline; agreement to use such a method throughout the study
* Capacity to provide informed consent; provision of a signed and dated consent form

Exclusion Criteria

* Poorly managed general medical condition
* Pregnant or breast feeding
* Implanted device in the back
* Lifetime history of a serious suicide attempt
* Clinically inappropriate for participation in the study as determined by the study team
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Utah

OTHER

Sponsor Role lead

Responsible Party

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Jan Kubanek

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jan Kubanek, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Utah

Daniel Odell, MD

Role: STUDY_CHAIR

University of Utah

Locations

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University of Utah

Salt Lake City, Utah, United States

Site Status

Countries

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United States

Other Identifiers

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IRB_00175546

Identifier Type: -

Identifier Source: org_study_id

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