Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
149 participants
INTERVENTIONAL
2019-04-01
2021-04-01
Brief Summary
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Detailed Description
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Objective 1 aims to determine the effects of noninvasive brain stimulation on the pain-related brain activities during pain processing. We hypothesize that noninvasive brain stimulation approaches will increase or decrease cortical activity upon processing painful input.
Objective 2 aims to determine the effects of noninvasive brain stimulation on pain intensity and/or pain-related behavioral assessments. We hypothesize that noninvasive brain stimulation will influence pain-intensity and/or pain-related behavioral assessments.
Objective 3 aims to investigate the correlation between brain activity and pain relief after noninvasive brain stimulation. We hypothesize that noninvasive brain stimulation will suppress cortical activity in pain-related brain areas, reduce pain intensity, and/or improve pain-related behavioral assessments.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Healthy Human Subjects
Healthy human subjects will complete study procedures in the research lab at UVA. They will complete pain-related behavioral questionnaires and undergo experimental pain testing for temperature and laser stimuli for real and control conditions of brain stimulation.
Transcranial Focused Ultrasound
Non-invasive brain stimulation technique
Transcranial Magnetic Stimulation
Non-invasive brain stimulation technique
Acute Pain Patients
Acute Pain Patients will complete study procedures in the hospital or clinic at UVA. They will complete pain-related behavioral questionnaires and undergo experimental pain testing for temperature and laser stimuli for real and control conditions of brain stimulation, as well as rate their ongoing pain.
Transcranial Focused Ultrasound
Non-invasive brain stimulation technique
Transcranial Magnetic Stimulation
Non-invasive brain stimulation technique
Chronic Pain Patients
Chronic Pain Patients will complete study procedures in the hospital or clinic at UVA. They will complete pain-related behavioral questionnaires and undergo experimental pain testing for temperature and laser stimuli for real and control conditions of brain stimulation, as well as rate their ongoing pain.
Transcranial Focused Ultrasound
Non-invasive brain stimulation technique
Transcranial Magnetic Stimulation
Non-invasive brain stimulation technique
Interventions
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Transcranial Focused Ultrasound
Non-invasive brain stimulation technique
Transcranial Magnetic Stimulation
Non-invasive brain stimulation technique
Eligibility Criteria
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Inclusion Criteria
* Chronic and Acute pain patients: must have an MRI (for ultrasound targeting)
Exclusion Criteria
* History of brain surgery
* History of seizure
* Pregnant
* Have alcohol consumption exceeding 50 drinks/month
* Have history of opioid abuse (all subjects), or any recent opioid use (healthy controls)
* Have implant like pacemaker and aneurysm clip
* Current of psychiatric disease such as anxiety or depression, which is not optimally treated
* Current infection
* Current wound on the skin of upper and lower extremities
* Chronic pain patients: current chronic pain is not optimal controlled by pain medications (i.e. Pain VAS \>5)
18 Years
80 Years
ALL
Yes
Sponsors
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University of Virginia
OTHER
Responsible Party
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Locations
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University of Virginia
Charlottesville, Virginia, United States
Countries
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Facility Contacts
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Other Identifiers
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21311
Identifier Type: -
Identifier Source: org_study_id
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