Subcutaneous Nerve Stimulation for Failed Back Surgery Syndrome (FBSS) Patients

NCT ID: NCT01818297

Last Updated: 2017-09-21

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

137 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2016-03-31

Brief Summary

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The purpose of this study is to assess the safety and efficacy of Subcutaneous Nerve Stimulation (SQS) (also known as Peripheral Nerve Stimulation \[PNS\]) in the reduction of chronic, intractable post-surgical back pain in adults.

Detailed Description

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This study is a multi-center, prospective, randomized (1:1) parallel-group design.

Conditions

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Failed Back Surgery Syndrome Post-laminectomy Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Treatment

Treatment settings of Medtronic PrimeAdvanced® neurostimulator system implant

Group Type ACTIVE_COMPARATOR

PrimeAdvanced® neurostimulator system

Intervention Type DEVICE

Neurostimulator and associated components

Control

Control settings of Medtronic PrimeAdvanced® neurostimulator system implant

Group Type OTHER

PrimeAdvanced® neurostimulator system

Intervention Type DEVICE

Neurostimulator and associated components

Interventions

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PrimeAdvanced® neurostimulator system

Neurostimulator and associated components

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Have persistent back pain for at least 6 months
* Had back surgery at least 6 months ago
* Have tried pain medications and physical therapy
* Read and understand written English or Spanish
* Male or non-pregnant female. If female of child-bearing potential, and if sexually active, must be using a medically-acceptable method of birth control during study participation
* Willing and able to undergo surgical implant procedure, attend visits as scheduled, and comply with the study requirements
* Have an expected lifespan greater than 12 months

Exclusion Criteria

* Have leg pain in addition to back pain.
* Currently enrolled in or plan to enroll in another drug and/or device study
* Have peripheral vascular disease, peripheral neuropathy, small-fiber neuropathy, or fibromyalgia
* Have an active systemic infection or are immunocompromised
* Will be exposed to diathermy or anticipate needing a full-body MRI scan
* Currently have an implantable cardiac pacemaker, defibrillator, or neurostimulator
* Treated with spinal cord stimulation, peripheral nerve stimulation, an intrathecal drug delivery system or requires additional back surgery
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MedtronicNeuro

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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George Mandybur, MD

Role: PRINCIPAL_INVESTIGATOR

Mayfield Clinic, University of Cincinnati

Locations

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Valley Pain Consultants

Phoenix, Arizona, United States

Site Status

HOPE Research Institute

Phoenix, Arizona, United States

Site Status

Coastal Pain Research

Carlsbad, California, United States

Site Status

Pain Medicine Associates

Fountain Valley, California, United States

Site Status

Florida Pain Institute

Merritt Island, Florida, United States

Site Status

Advanced Medicine and Pain Management Research

Miami, Florida, United States

Site Status

Compass Research, LLC

Orlando, Florida, United States

Site Status

Emory University School of Medicine

Atlanta, Georgia, United States

Site Status

Rush University Medical Center

Chicago, Illinois, United States

Site Status

University of Illinois at Chicago

Chicago, Illinois, United States

Site Status

University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Willis Knighton River Cities Clinical Research Center

Shreveport, Louisiana, United States

Site Status

Comprehensive Pain and Rehabilitation

Pascagoula, Mississippi, United States

Site Status

Columbia Interventional Pain Center, LLP

Columbia, Missouri, United States

Site Status

Mercy Medical Research Institute

Springfield, Missouri, United States

Site Status

NYU Langone Medical Center

New York, New York, United States

Site Status

Mayfield Clinic

Cincinnati, Ohio, United States

Site Status

University Hospitals Case Medical Center

Cleveland, Ohio, United States

Site Status

Ohio State University

Columbus, Ohio, United States

Site Status

Summa Western Reserve Hospital

Cuyahoga Falls, Ohio, United States

Site Status

DNA Advanced Pain Treatment Center

Greensburg, Pennsylvania, United States

Site Status

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status

Southern Spine Institute

Mt. Pleasant, South Carolina, United States

Site Status

Austin Pain Associates

Cedar Park, Texas, United States

Site Status

Space City Pain Specialists

Webster, Texas, United States

Site Status

Lifetree Clinical Research

Salt Lake City, Utah, United States

Site Status

Wisconsin Health Center Surgery Center

Greenfield, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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G120146

Identifier Type: OTHER

Identifier Source: secondary_id

1666

Identifier Type: -

Identifier Source: org_study_id