Efficacy of Virtual Reality Exercises on Sarcopenia in Patients With Liver Transplantation

NCT ID: NCT06209073

Last Updated: 2024-01-17

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-25
• Study Completion Date: 2024-06-20

Brief Summary

This study will be conducted to investigate the effect of virtual reality exercises on hand grip strength, pinch strength, quadriceps muscle strength, exercise capacity, fatigue, and quality of life in patients with liver transplantation.

Detailed Description

Liver transplantation (LT) continues to prove to be the best choice for curing patients with end-stage liver disease (ESLD) . Management strategies in peri-transplantation care have significantly improved the outcomes of patients after LT. One of the most challenging tasks of LT is defining which patients are clinically appropriate for this therapy. Evaluating disease severity for patients with ESLD is a serious challenge for liver transplant surgeons, and there is a critical need for better methods of risk stratification. The most common complications involved include ascites, hepatic encephalopathy, and variceal bleeding; however, severe muscle wasting or sarcopenia is the most common and frequently undiagnosed complications that negatively impact survival, quality of life, and response to stressors, such as infections and surgeries. Virtual reality (VR) is an interactive, 3-dimensional computer experience occurring in real time. It allows the users to participate in multisensory and multidimensional virtual environments . It provides the participants with real-time auditory, visual, and proprioception sensory feedback. It also provides a safe virtual exercise environment. sixty patients with liver transplantation will be assigned randomly to two groups; experimental group will receive virtual reality exercise plus traditional therapy for six weeks, control group will receive traditional therapy alone for six weeks

Conditions

Sarcopenia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

virtual reality exercise

the patients will receive virtual reality and conventional therapy three times a week for six weeks

Group Type: EXPERIMENTAL

Virtual Reality exercise

Intervention Type: OTHER

after explaining the treatment method for patients, the patients will perform full body aerobic exercise by applying kick boxing to destroy walls of rock; the patient moves most of body muscles in this game. He or she flex and extend the shoulder and the elbow with flexion and extension in the knee. squatting exercise, endurance exercise, coordination for arm and shoulder exercise will also performed in virtual reality

conventional treatment

Intervention Type: OTHER

the patients will receive conventional treatment in the form of aerobic exercise, resistance exercise and endurance exercise.

conventional treatment

the patients will receive conventional treatment three times a week for six weeks

Group Type: EXPERIMENTAL

conventional treatment

Intervention Type: OTHER

the patients will receive conventional treatment in the form of aerobic exercise, resistance exercise and endurance exercise.

Interventions

Virtual Reality exercise

after explaining the treatment method for patients, the patients will perform full body aerobic exercise by applying kick boxing to destroy walls of rock; the patient moves most of body muscles in this game. He or she flex and extend the shoulder and the elbow with flexion and extension in the knee. squatting exercise, endurance exercise, coordination for arm and shoulder exercise will also performed in virtual reality

Intervention Type: OTHER

conventional treatment

the patients will receive conventional treatment in the form of aerobic exercise, resistance exercise and endurance exercise.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

Sixty patients suffer from sarcopenia with liver transplantation. The age of patients ranges from (18:65) years. All patients must be conscious. Patients suffer from muscle weakness Patients suffer from fatigue Patients with low muscle endurance Patients' cases must be stable to deal with them

Exclusion Criteria

Patients will be excluded if they have any of the following:

Any sign of acute rejection of the transplanted organ Acute hemorrhage Electrolyte imbalance Physiological instability Sever neurologic complication Sever cardiovascular co-morbidities

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Nabil Mahmoud Ismail Abdel-Aal

Principal Investigator: nabil mahmoud ismail abdel-Aal

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Sara A Elshrief, Bsc

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Locations

Faculty of Physical Therapy

Cairo, , Egypt

Countries

Egypt

Central Contacts

Sata A Elshrief, Bsc

Role: CONTACT

ssyara14@yahoo.com

01065095990 ext. +2

Nabil M Ismail, Assist. Prof

Role: CONTACT

nabil.mahmoud@cu.edu.eg

0120133613 ext. +2

Other Identifiers

P.T.REC/012/003915

Identifier Type: -

Identifier Source: org_study_id