High-Intensity Exercise in Older Adults

NCT ID: NCT06199661

Last Updated: 2024-01-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 4 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-03-06
• Study Completion Date: 2023-06-01

Brief Summary

The goal of this interventional study was to test the high-intensity interval training called Aphasia Physical Exercise (APEX) in healthy older adults. The main questions it aimed to answer were:

1. what is the safety and feasibility of APEX?

2. what are APEX's acute physiological effects?

3. what is APEX's effects on functional fitness?

4. what is APEX's effects on cognition?

Participants underwent:

• Baseline testing session (#1) with cognitive measures only (a week before the Pre-exercise session);
• Pre-exercise session (#2) with maximum oxygen consumption and heart rate assessment, functional fitness and cognitive measures (3-7 days before the start of the exercise program);
• APEX program, two APEX classes per week for four weeks (eight classes in total);
• Post-exercise session (#3), functional fitness and cognitive measures, (0-2 days after the end of the exercise program).

Conditions

Functional Fitness; Cognitive Abilities

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

APEX

Physical exercise intervention based on high-intensity interval training

Group Type: EXPERIMENTAL

APEX

Intervention Type: BEHAVIORAL

Three phases: warm-up, high-intensity interval training (HIIT) phase, cool-down. A 10-minute warm-up included deep breathing meditation and dynamic joint mobility exercises. Then, a 40-minute strength and balance workout in HIIT format with five different high-intensity (HI) exercises interspersed with five different postural stability recovery exercises. The HI intervals focused on enhancing cardiovascular fitness, muscle strength, and motor performance. The recovery intervals incorporated balance and mobility exercises. The HI exercises lasted 30 seconds for the first three weeks and then increased to 45 seconds in the fourth week while the recovery exercises lasted 60 seconds throughout the entire intervention. The HIIT phase was repeated three times in the 40 minute block. Lastly, a 10-minute cooldown consisting of standing and seated exercises similar to the warm-up.

Interventions

APEX

Three phases: warm-up, high-intensity interval training (HIIT) phase, cool-down. A 10-minute warm-up included deep breathing meditation and dynamic joint mobility exercises. Then, a 40-minute strength and balance workout in HIIT format with five different high-intensity (HI) exercises interspersed with five different postural stability recovery exercises. The HI intervals focused on enhancing cardiovascular fitness, muscle strength, and motor performance. The recovery intervals incorporated balance and mobility exercises. The HI exercises lasted 30 seconds for the first three weeks and then increased to 45 seconds in the fourth week while the recovery exercises lasted 60 seconds throughout the entire intervention. The HIIT phase was repeated three times in the 40 minute block. Lastly, a 10-minute cooldown consisting of standing and seated exercises similar to the warm-up.

Intervention Type: BEHAVIORAL

Other Intervention Names

Physical exercise intervention incorporating high-intensity interval training

Eligibility Criteria

Inclusion Criteria

• Between the ages of 50 and 80
• Ambulatory and community-dwelling
• Able to travel to University of San Francisco for weekly exercise classes
• No serious underlying health or neurological conditions

Exclusion Criteria

• Inability to complete physical function assessment or inability to do a chair stand without using hands
• Use of antidiabetic medications
• Use of testosterone supplement or replacement
• Clinical disorder precluding/interfering with participation or assessments (identified by Physical Activity Readiness Questionnaire (PAR-Q+)), including: unstable angina, arrhythmia, uncontrolled hypertension, end stage renal disease on hemodialysis, lower extremity amputation or paralysis, neurological conditions causing functional or pronounced cognitive impairments, active malignancy except for non-melanomatous skin cancers
• Previous neurological history such as stroke, traumatic brain injury, multiple sclerosis, long-term pre-stroke seizures, Parkinson's, Alzheimer's, etc.
• Unable to provide consent

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of San Francisco

OTHER

Sponsor Role: collaborator

University of California, Berkeley

OTHER

Sponsor Role: lead

Responsible Party

Maria Ivanova

Research Scientist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of San Francisco

San Francisco, California, United States

Countries

United States

Other Identifiers

1884

Identifier Type: -

Identifier Source: org_study_id