Gene x Environment Interplay in Developmental Dyslexia Treatment: A Round-trip Translation Between Humans and Animal

NCT ID: NCT06186882

Last Updated: 2024-01-02

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-04-30
• Study Completion Date: 2026-04-30

Brief Summary

Developmental dyslexia affects 7% of school-age children (Male:Female ratio of 1.5:1) and incurs disadvantages in education and occupation. Scientific progress concerning the etiology of developmental dyslexia evidenced the complex gene-environment interaction. The DCDC2-READ1 deletion associates with reading skills and affects the magnocellular-dorsal stream in humans and animals. DCDC2 modifies neural activity within the excitatory pathways. The magnocellular-dorsal stream mediates the function of the attention network. Difficulties in spatial and temporal attention shifting impair letter-to-speech sound integration increasing neural noise. Action video games improve the efficiency of the magnocellular-dorsal stream. The aim of this cutting-edge, round trip translation study is threefold: 1.to unravel new insights behind the pathophysiology of developmental dyslexia, 2. to assess gene-environment interaction effects on developmental dyslexia endophenotypes, and 3. to identify useful clues to foster the identification of new, personalized treatments.

Conditions

Reading Disorder

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

ENVIRONMENTAL STIMULATION

Group Type: EXPERIMENTAL

Action Video-Game

Intervention Type: BEHAVIORAL

Thanks to their specific characteristics (presentation of multiple peripheral, rapidly moving, spatio-temporally unpredictable stimuli), Action Video-Games improve reading skills through their effects on the Magnocellular-Dorsal stream. Training will consist of 20 days of Action Video-Games sessions of 1 hour each, three times per week.

Interventions

Action Video-Game

Thanks to their specific characteristics (presentation of multiple peripheral, rapidly moving, spatio-temporally unpredictable stimuli), Action Video-Games improve reading skills through their effects on the Magnocellular-Dorsal stream. Training will consist of 20 days of Action Video-Games sessions of 1 hour each, three times per week.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• 5-years old pre-readers,
• normal intelligence quotient,
• no main counter indications for magnetic resonance acquisition,
• no previous diagnosis of any neurodevelopmental disorders.

Exclusion Criteria

• intelligence quotient below the average range,
• presence of counter indications for magnetic resonance acquisition,
• previous diagnosis of any neurodevelopmental disorders.

• Minimum Eligible Age: 5 Years
• Maximum Eligible Age: 6 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Università degli studi di Bergamo

UNKNOWN

Sponsor Role: collaborator

IRCCS Eugenio Medea

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Scientific Institute IRCCS E Medea

Bosisio Parini, LC, Italy

Site Status: RECRUITING

Countries

Italy

Central Contacts

Sara Mascheretti

Role: CONTACT

sara.mascheretti@lanostrafamiglia.it

031877895

Facility Contacts

Sara Mascheretti

Role: primary

sara.mascheretti@lanostrafamiglia.it

031877985

Other Identifiers

GR-2021-12375102

Identifier Type: -

Identifier Source: org_study_id