Neural Mechanisms of Successful Intervention in Children With Dyslexia

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-01

Study Completion Date

2024-09-01

Brief Summary

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Dyslexia, an impairment in accurate or fluent word recognition, is the most common learning disability affecting roughly ten percent of children. This proposal capitalizes on cutting edge neuroimaging methods, in combination with reading education programs, to generate a new understanding of how successful reading education shapes the development of the brain circuits that support skilled reading. A deeper understanding of the mechanisms of successful remediation of dyslexia, and individual differences in learning, will pave the way for personalized approaches to dyslexia treatment.

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Detailed Description

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Conditions

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Dyslexia, Developmental

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

subjects are seen before and after receiving 8 weeks of reading instruction

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Lindamood-Bell Seeing Stars

Subjects receive reading instruction focusing on the building blocks of reading

Group Type EXPERIMENTAL

Lindamood-Bell Seeing Stars

Intervention Type BEHAVIORAL

Seeing Stars in a curriculum developed by Lindamood-Bell. It is published and openly available. It involves systematic training in the building blocks of skilled reading.

Control

Subjects are followed longitudinally but do not receive intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Lindamood-Bell Seeing Stars

Seeing Stars in a curriculum developed by Lindamood-Bell. It is published and openly available. It involves systematic training in the building blocks of skilled reading.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Reading difficulties defined as low scores on standardized measures of reading skills

Exclusion Criteria

* no major contraindication for MRI (braces, metal implants, pacemakers, vascular stents, or metallic ear tubes).
* Because the study involves measurements of reading and language ability, new recruits will be native English speakers.
* Subjects have no history of neurological disorder, significant psychiatric problems
* exclude claustrophobic subjects since an MRI might be uncomfortable for them.

Minimum Eligible Age

8 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes