Stuttering and Neuromodulation

NCT ID: NCT07222163

Last Updated: 2025-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-04

Study Completion Date

2027-10-31

Brief Summary

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The purpose of this study is to collect preliminary data on the efficacy of transcranial direct current stimulation (tDCS) combined with traditional behavioral techniques to reduce stuttering severity and negative impact in adults who stutter. The study also aims to explore neuroplastic changes (i.e., regional activation and functional connectivity) resulting from combined tDCS + speech therapy.

Detailed Description

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Conditions

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Stuttering

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Behavioral speech therapy combined with active tDCS

Each participant will complete ten treatment sessions over approximately ten weeks. In each session, participants will receive active tDCS for 30 minutes while concurrently engaging in behavioral speech therapy. Active stimulation will include a 30-second ramp-up to 2.0 mA, 30 minutes of continuous stimulation, and a 30-second ramp-down.

Group Type EXPERIMENTAL

Soterix Medical 1x1 tDCS system

Intervention Type DEVICE

Stimulation (2.0 mA for 30 minutes) will occur during speech therapy sessions focused on practicing speech techniques. Sham stimulation will mimic the physical sensation without active current.

Speech therapy sessions

Intervention Type BEHAVIORAL

Each of the ten weekly sessions will begin with 15 minutes of strategy practice, providing participants with the opportunity to rehearse light contact and easy onset techniques prior to the tDCS-enhanced speaking task.

Behavioral speech therapy combined with sham tDCS

Each participant will complete ten treatment sessions over approximately ten weeks. In each session, participants will receive sham tDCS for 30 minutes while concurrently engaging in behavioral speech therapy. Sham stimulation will involve the same ramp-up and ramp-down but with no current delivered during the 30-minute period to maintain blinding.

Group Type SHAM_COMPARATOR

Soterix Medical 1x1 tDCS system

Intervention Type DEVICE

Stimulation (2.0 mA for 30 minutes) will occur during speech therapy sessions focused on practicing speech techniques. Sham stimulation will mimic the physical sensation without active current.

Speech therapy sessions

Intervention Type BEHAVIORAL

Each of the ten weekly sessions will begin with 15 minutes of strategy practice, providing participants with the opportunity to rehearse light contact and easy onset techniques prior to the tDCS-enhanced speaking task.

Interventions

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Soterix Medical 1x1 tDCS system

Stimulation (2.0 mA for 30 minutes) will occur during speech therapy sessions focused on practicing speech techniques. Sham stimulation will mimic the physical sensation without active current.

Intervention Type DEVICE

Speech therapy sessions

Each of the ten weekly sessions will begin with 15 minutes of strategy practice, providing participants with the opportunity to rehearse light contact and easy onset techniques prior to the tDCS-enhanced speaking task.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Adults aged 18 to 65 years.
2. Diagnosis of developmental stuttering, verified by a licensed speech-language pathologist.
3. Mild-to-moderate or greater stuttering severity, defined as a score of 20 or higher on the Stuttering Severity Instrument-Fourth Edition (SSI-4).
4. English as a primary language.
5. Right-handedness (to minimize variability in neural lateralization).
6. Willing and able to attend all study sessions and follow study procedures.

Exclusion Criteria

1. Have a history of neurological, psychiatric, or medical conditions that are contraindicated for tDCS.
2. Are currently taking medications known to affect cortical excitability.
3. Have a history of seizures or epilepsy.
4. Are pregnant or planning to become pregnant during the study period.
5. Have metal implants in the head (excluding dental work) or other contraindications to electrical brain stimulation.
6. Any skin disorder or skin sensitive area near stimulation locations.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric S. Jackson

Role: PRINCIPAL_INVESTIGATOR

NYU Langone Health

Locations

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NYU Langone Health

New York, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Eric S. Jackson

Role: CONTACT

212-992-9470

Other Identifiers

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25-00866

Identifier Type: -

Identifier Source: org_study_id

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