The Effect of the Non-invasive Brain Stimulation on the Speech Fluency Enhancement

NCT ID: NCT03990168

Last Updated: 2020-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-01

Study Completion Date

2020-04-01

Brief Summary

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The aim of this study is to determine the effectiveness of concurrent transcranial direct current stimulation (tDCS) and fluency training in adults with developmental stuttering. We examine the severity of stuttering to investigate the effect of treatnment. In the control group the anodal tDCS and DAF will applied on six consecutive days (1 milliampere \[mA\] for 20 mins per day), and the control group will received the sham stimulation and DAF for the same time. The severity of stuttering measured by means of tasks and questionnaires before and after treatment sessions and 6 weeks after intervention.

Detailed Description

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Conditions

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Stuttering/ Developmental

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Experimental

Participants will receive one anodal tDCS at 1 mA intensity over the left superior temporal gyrus (T3 in 10-20 international system) and the cathode tDCS over the right orbitofrontal area (Fp2 in 10-20 international system). tDCS will be delivered for 20 minutes during fluency intervention for six consecutive days.

Group Type EXPERIMENTAL

Anodal tDCS

Intervention Type DEVICE

1 mA anodal tDCS positioned over left superior temporal gyrus and the cathode placed over the occipital lobe. The tDCS stimulation will be delivered for 20 minutes on 6 intervention days.

fluency intervention/ Delayed Auditory Feedback

Intervention Type BEHAVIORAL

Each participant complete three tasks include reading, conversation, and narration. Delayed auditory feedback will be used during these tasks. Each treatment session will take 20 minutes.

Sham Comparator

Participants will receive sham tDCS while the one anode electrode will be positioned over the left superior temporal gyrus and the cathode will be placed over the right orbitofrontal similar to the active mode. The sham stimulation will break down after 30 seconds at the beginning of 20 minutes of fluency intervention for six consecutive days.

Group Type SHAM_COMPARATOR

fluency intervention/ Delayed Auditory Feedback

Intervention Type BEHAVIORAL

Each participant complete three tasks include reading, conversation, and narration. Delayed auditory feedback will be used during these tasks. Each treatment session will take 20 minutes.

Sham tDCS

Intervention Type DEVICE

The anodal tDCS positioned over left superior temporal gyrus and the cathode placed over the occipital lobe. The current of sham stimulation will involve 30 seconds of stimulation at the beginning of the 20 minutes on 6 intervention days.

Interventions

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Anodal tDCS

1 mA anodal tDCS positioned over left superior temporal gyrus and the cathode placed over the occipital lobe. The tDCS stimulation will be delivered for 20 minutes on 6 intervention days.

Intervention Type DEVICE

fluency intervention/ Delayed Auditory Feedback

Each participant complete three tasks include reading, conversation, and narration. Delayed auditory feedback will be used during these tasks. Each treatment session will take 20 minutes.

Intervention Type BEHAVIORAL

Sham tDCS

The anodal tDCS positioned over left superior temporal gyrus and the cathode placed over the occipital lobe. The current of sham stimulation will involve 30 seconds of stimulation at the beginning of the 20 minutes on 6 intervention days.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* History of developmental stuttering
* Participants diagnosed with moderate to severe stuttering
* Right handed
* Native speaker of Farsi

Exclusion Criteria

* Speech or language disorders other than stuttering
* Received stuttering treatment within the past year
* Hearing loss
* History of neurological or psychiatric disorders
* History of seizure
* Taking any medication that may affect brain function such as anti-depressants
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Iran University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Moin

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Reyhane Mohamadi

Role: STUDY_DIRECTOR

Iran University of Medical Sciences

Locations

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Narges Moin

Tehran, , Iran

Site Status

Countries

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Iran

References

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Moein N, Mohamadi R, Rostami R, Nitsche M, Zomorrodi R, Ostadi A, Keshtkar A. Delayed Auditory Feedback and Transcranial Direct Current Stimulation Treatment for the Enhancement of Speech Fluency in Adults Who Stutter: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2020 Apr 21;9(4):e16646. doi: 10.2196/16646.

Reference Type DERIVED
PMID: 32314973 (View on PubMed)

Other Identifiers

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98-2-75-15001

Identifier Type: -

Identifier Source: org_study_id