Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia
NCT ID: NCT06185023
Last Updated: 2025-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
12 participants
INTERVENTIONAL
2023-12-12
2025-12-31
Brief Summary
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* Is it feasible for stroke survivors with aphasia to participate in a long in-person physical exercise program?
* Does participation in a physical exercise program lead to physical fitness, cognitive, language and/or psychological changes?
Participants can take part in two different physical exercise interventions:
* Low intensity intervention (control intervention);
* High-intensity physical exercise intervention (target intervention).
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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High-intensity physical exercise
The participants will take part in a high-intensity Aphasia Physical EXercise (APEX) intervention designed specifically for individuals with chronic post-stroke aphasia for 8 weeks.
High-intensity physical exercise
We have developed a new exercise program specifically designed for individuals with post-stroke aphasia, Aphasia Physical EXercise (APEX), to provide a safe, stroke- and aphasia-friendly physical exercise intervention to achieve optimal physical fitness and cognitive/language gains. This intervention, based on published research and clinical practice recommendations, is a high-intensity interval training full-body workout optimized to accommodate the range of motor abilities and general deconditioning observed in stroke survivors.
High-intensity physical exercise - remote
The participants will take part in a high-intensity Aphasia Physical EXercise (APEX) intervention designed specifically for individuals with chronic post-stroke aphasia for 4 weeks. The first week will be delivered in-person, while weeks 2-4 will be delivered remotely via live Zoom classes.
High-intensity physical exercise
We have developed a new exercise program specifically designed for individuals with post-stroke aphasia, Aphasia Physical EXercise (APEX), to provide a safe, stroke- and aphasia-friendly physical exercise intervention to achieve optimal physical fitness and cognitive/language gains. This intervention, based on published research and clinical practice recommendations, is a high-intensity interval training full-body workout optimized to accommodate the range of motor abilities and general deconditioning observed in stroke survivors.
Low-intensity physical exercise
The participants will participate in a low-intensity non-aerobic exercise program for 2 weeks.
Low-intensity physical exercise
As an active control intervention, a low-intensity non-aerobic exercise program was selected that mirrors more closely the standard-of-care physical therapy currently provided to stroke patients. This control intervention will offer the same level of participant involvement and type of exercises, but without the intensity element, i.e., it will not incorporate the cardiovascular and the strengthening components.
Interventions
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Low-intensity physical exercise
As an active control intervention, a low-intensity non-aerobic exercise program was selected that mirrors more closely the standard-of-care physical therapy currently provided to stroke patients. This control intervention will offer the same level of participant involvement and type of exercises, but without the intensity element, i.e., it will not incorporate the cardiovascular and the strengthening components.
High-intensity physical exercise
We have developed a new exercise program specifically designed for individuals with post-stroke aphasia, Aphasia Physical EXercise (APEX), to provide a safe, stroke- and aphasia-friendly physical exercise intervention to achieve optimal physical fitness and cognitive/language gains. This intervention, based on published research and clinical practice recommendations, is a high-intensity interval training full-body workout optimized to accommodate the range of motor abilities and general deconditioning observed in stroke survivors.
Eligibility Criteria
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Inclusion Criteria
* at least 6 months from the last stroke;
* proficient in English before the stroke;
* at least 8 years of education;
* between the ages of 18 and 80;
* independent with ambulation without a device (single-point cane accepted);
* medically stable with no contraindications to participate in regular physical exercise as determined by the patient's own primary care provider or other treating provider.
Exclusion Criteria
* significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing;
* per self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise.
18 Years
80 Years
ALL
No
Sponsors
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University of California, San Francisco
OTHER
University of San Francisco
OTHER
California State University, East Bay
OTHER
University of California, Berkeley
OTHER
Responsible Party
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Maria Ivanova
Assistant Professional Researcher
Principal Investigators
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Maria Ivanova, PhD
Role: PRINCIPAL_INVESTIGATOR
University of California, Berkeley
Locations
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University of California Berkeley
Berkeley, California, United States
California State University East Bay
Hayward, California, United States
University of San Francisco
San Francisco, California, United States
University of California San Francisco
San Francisco, California, United States
Countries
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Other Identifiers
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056427-002
Identifier Type: -
Identifier Source: org_study_id
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