Speech and Language Therapy After Stroke

NCT ID: NCT00713050

Last Updated: 2013-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-08-31

Study Completion Date

2012-01-31

Brief Summary

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Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.

Detailed Description

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Detailed information will follow in the next progress report.

Conditions

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Ischemic Stroke

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Experimental

Computer-based Aphasia therapy

Group Type EXPERIMENTAL

Imitate Therapy

Intervention Type BEHAVIORAL

Imitation-based computer therapy

Control

Control Arm - Healthy subjects.

Group Type ACTIVE_COMPARATOR

Imitate Therapy

Intervention Type BEHAVIORAL

Imitation-based computer therapy

Interventions

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Imitate Therapy

Imitation-based computer therapy

Intervention Type BEHAVIORAL

Other Intervention Names

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Imitate

Eligibility Criteria

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Inclusion Criteria

1. Single ischemic infarction in the MCA territory involving the cerebral cortex (confirmed by CT or MRI)
2. Aphasia
3. Visual attention and language comprehension sufficient to perform imitation fMRI tasks
4. Right handed (prior to stroke)

Exclusion Criteria

Exclusions to the study are people with cardiac pacemakers, claustrophobia, neurosurgical clips, or cognitive impairments too severe to permit cooperation with cognitive tasks in an MRI scanner.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

Sponsor Role collaborator

Shirley Ryan AbilityLab

OTHER

Sponsor Role collaborator

University of Chicago

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Steven Small, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Chicago

Locations

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Solodkin/Small Brain Circuits Laboratory

Irvine, California, United States

Site Status

University of California Irvine

Irvine, California, United States

Site Status

Countries

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United States

References

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Duncan ES, Schmah T, Small SL. Performance Variability as a Predictor of Response to Aphasia Treatment. Neurorehabil Neural Repair. 2016 Oct;30(9):876-82. doi: 10.1177/1545968316642522. Epub 2016 Apr 6.

Reference Type DERIVED
PMID: 27053642 (View on PubMed)

Other Identifiers

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5R01DC007488-05

Identifier Type: NIH

Identifier Source: secondary_id

View Link

13785A

Identifier Type: -

Identifier Source: org_study_id

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