Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation
NCT ID: NCT01221779
Last Updated: 2013-08-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
40 participants
INTERVENTIONAL
2011-01-31
2014-12-31
Brief Summary
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Detailed Description
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Thus, in the present project we aim to assess whether the outcome of intensive language training can be enhanced by adjuvant non-invasive brain stimulation. We will be using anodal transcranial direct current stimulation (atDCS) that has previously been shown to enhance (a) language and motor learning in healthy subjects and (b) motor recovery in stroke patients. Specifically, in a longitudinal group comparison design, two matched groups of patients with chronic anomia will receive two weeks of intensive language training with or without atDCS. Treatment effects will be assessed immediately after the two week intervention period and several months after the end of the training. We will also use functional and structural magnetic resonance imaging (MRI) to elucidate language network changes in the two groups.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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sham tDCS
Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
anodal tDCS
Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
Interventions
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Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
Eligibility Criteria
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Inclusion Criteria
* single first time left-hemisphere stroke
* fluent- or non-fluent chronic aphasia (more than six months post-stroke)
* anomia (PR\>10 and PR\<60 Aachen Aphasia Naming Subtest)
* native German Speaker
Exclusion Criteria
* alcoholism, severe psychiatric conditions, other neurological conditions
* other non-treated medical problems, severe microangiopathy
* pregnancy
18 Years
70 Years
ALL
No
Sponsors
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German Federal Ministry of Education and Research
OTHER_GOV
Charite University, Berlin, Germany
OTHER
Responsible Party
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Marcus Meinzer
Creutzfeldt Fellow
Principal Investigators
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Marcus Meinzer, PhD
Role: PRINCIPAL_INVESTIGATOR
Charite, University Medicine, Neurology
Agnes Flöel, MD
Role: STUDY_DIRECTOR
Charite, University Medicine, Neurology
Locations
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Charite, University Medicine, Dept. of Neurology
Berlin, , Germany
Countries
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Central Contacts
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Other Identifiers
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CATS01EO0801
Identifier Type: -
Identifier Source: org_study_id