Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS)
NCT ID: NCT01924702
Last Updated: 2015-02-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
24 participants
INTERVENTIONAL
2011-01-31
2015-12-31
Brief Summary
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Detailed Description
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Thus, in the present project the investigators aim to assess whether the outcome of intensive language training can be enhanced by adjuvant non-invasive brain stimulation. They will be using anodal transcranial direct current stimulation (atDCS) that has previously been shown to enhance (a) language and motor learning in healthy subjects and (b) motor recovery in stroke patients. Specifically, in a longitudinal group comparison design, two matched groups of patients with chronic anomia will receive two weeks of intensive language training with or without atDCS. Treatment effects will be assessed immediately after the two week intervention period and several months after the end of the training. The Investigators will also use functional and structural magnetic resonance imaging (MRI) to elucidate language network changes in the two groups.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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anodal tDCS
Intensive language therapy with anodal transcranial direct current stimulation
Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
transcranial direct current stimulation
1mA anodal over M1 primary motor cortex for 20min with 35cm/2 electrode, Cathode (100cm/2) contralateral
sham tDCS
Intensive language therapy with Sham-tDCS
Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
transcranial direct current stimulation
1mA anodal over M1 primary motor cortex for 20min with 35cm/2 electrode, Cathode (100cm/2) contralateral
Interventions
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Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
transcranial direct current stimulation
1mA anodal over M1 primary motor cortex for 20min with 35cm/2 electrode, Cathode (100cm/2) contralateral
Eligibility Criteria
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Inclusion Criteria
* aphasia due to stroke with naming impairment
* German as first language
* first-ever stroke
Exclusion Criteria
* history of severe alcohol or drug abuse, psychiatric illnesses like severe depression, poor motivational capacity
* dementia
* contraindications for Magnetic Resonance Imaging or transcranial direct current stimulation
18 Years
80 Years
ALL
No
Sponsors
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Charité Neurocure AG Flöel
OTHER
Responsible Party
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Principal Investigators
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Agnes Floeel, Prof MD
Role: PRINCIPAL_INVESTIGATOR
Charite University, Berlin, Germany
Locations
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Charite
Berlin, , Germany
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CATS02EO0801
Identifier Type: -
Identifier Source: org_study_id
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